Accelerated Progression and Morbidity in Patients With Aortic Stenosis on Chronic Dialysis

概要

論文の詳細を見る
Background Progression of aortic stenosis (AS) influences the prognosis in chronic dialysis (CD) patients, but there have been few studies in Japanese patient populations. Methods and Results The progression of AS was examined in 16 CD patients (68±10 years) and 82 non-dialysis patients (73±11 years). The mean follow-up was 32 and 40 months, respectively. The calcium-phosphate product was increased in CD patients (49±14mg/dl vs 30±5mg/dl; p<0.0001). At entry, the peak transaortic gradient detected by Doppler echocardiography was lower in CD patients (42±12mmHg vs 57±22mmHg; p<0.05). At follow-up, there was no difference between the 2 groups in that value (69±31mmHg vs 71±27mmHg). Decreasing rate of calculated aortic valvular area was increased in CD patients (0.14±0.13cm^2/year vs 0.06±0.09cm^2/year; p<0.05) and the calcification of the aortic valve was more severe at follow up in CD patients. The mortality was higher in CD patients (75 vs 28%; p<0.001). Conclusions AS appeared to progress rapidly in CD patients and therefore early aortic valve replacement may be necessary.
社団法人日本循環器学会の論文
2005-11-20