Inhibitory Effects of Sasa senanensis Rehder Extract (SE) on Calcium-Ionophore A23187 : Induced Histamine Release From Rat Peritoneal Exudate Cells
スポンサーリンク
概要
- 論文の詳細を見る
The effects of Sasa senanensis Rehder extract (SE) by alkaline hydrolysis on histamine release from rat peritoneal exudate cells (PECs) were examined. Preincubation with SE for 5 min suppressed calcium-ionophore A23187-induced histamine release in a concentration-dependent manner. A23187 evoked a quick increase in cytoplasmic free calcium ([Ca2+]i) levels in the presence of extracellular calcium. Preincubation with SE also had an inhibitory effect on calcium influx increases induced by A23187. These results indicate that SE prevents degranulation from rat PECs by inhibiting [Ca2+]i level elevation.
- 社団法人 日本薬理学会の論文
- 1999-04-01
著者
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OGUCHI KATSUJI
Department of Pharmacology, School of Medicine, Showa University
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IWAI Shinichi
Department of Pharmacology, School of Medicine, Showa University
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Oguchi Katsuji
Dep. Of Pharmacology School Of Medicine Showa Univ. Jpn
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Oguchi K
Showa Univ. Tokyo Jpn
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Oguchi Katsuji
Department Of Pharmacology School Of Medicine Showa University
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Oguchi Katsuji
Department Of Pharmacology Showa University School Of Medicine
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TSUJI MAYUMI
Department of Internal Medicine, Osaka Kosei-Nenkin Hospital
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Tsuji Mayumi
Department Of Internal Medicine Osaka Kosei-nenkin Hospital
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Iwai Shinichi
Department Of Pharmacology School Of Medicine Showa University
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Iwai Shin-ichi
Department Of Pharmacology Showa University School Of Medicine
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Yamazaki Yukako
Department Of Pharmacology School Of Medicine Showa University
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OKAZAKI Masako
Department of Pharmacology, Showa University School of Medicine
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KANDA Yuko
Department of Pharmacology, School of Medicine, Showa University
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Okazaki M
Department Of Pharmacology Showa University School Of Medicine
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Okazaki Masako
Department Of Orthodontics School Of Dentistry University Of Tokushima
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Kanda Yuko
Department Of Pharmacology School Of Medicine Showa University
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TSUJI Mayumi
Department of Pharmacology, School of Medicine, Showa University
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OGUCHI Katsuji
Department of Pharmacology, Showa University School of Medicine
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