Pharmacokinetics of cefmetazole in elderly patients and healthy volunteers.

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The pharmacokinetics of cefmetazole were investigated in 7 elderly patients (4 males, 3 females) and in 5 healthy volunteers (males). The drug was given in travenously at 10 mg/kg. The creatinine, clearance values of the elderly patients and healthy volunteers were 53.6 to 64.5 ml/min and 93.7 ml/min, respectively. The concentrations of cefmetazole in the serum and urine were determined by bioassay, and pharmacokinetic parameters were calculated on the basis of a two-compartment open model. The cumulative urinary excretion of cefmetazole at 8 hr after its injection was about 90% of the total dose in healthy volunteers, and about 60% of the dose in elderly patients. A negative correlation between age and the elimination rate constant (β), and a posltive correlation between age and the volume of distribution were observed. From these results, it was suggested that the decreased renal function reduced urinary excretion of cefmetazole in elderly patients, while the increased volume of distribution of cefmetazole, in particular, in bedridden elderly patients may be caused by age.
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