Membrane stabilizing action of NCO-650 and its congeners.
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概要
- 論文の詳細を見る
NCO-650 and its congeners and two other antiallergics, disodium cromoglycate and tranilast, were studied to determine the degree of protection of rat erythrocytes against hypotonic hemolysis, the reduction of the surface tension of dipalmitoylphosphatidylcholine (DPPC) monolayer and the depression of the phase-transition temperature of DPPC liposome bilayers. NCO-650 was found to show the greatest hemolysis protection, reduction of the surface tension and depression of the phase-transition temperature, indicating that it possesses a significant affinity to cell membranes and a significant ability to stabilize cell membranes. Disodium cromoglycate and tranilast showed neither cell membrane affinity nor hemolysis protection, although they inhibit histamine release from mast cells like NCO-650 and its congeners. The significant membrane stabilizing action of NCO-650 must be related, at least in part, to its extraordinarily high lipid solubility.
- 公益社団法人 日本薬理学会の論文
著者
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Arakawa Kasumi
Department Of Anesthesiology The University Of Kansas Medical Center
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Sakamoto Koji
Department Of Pharmacology School Of Medicine Showa University
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Goto Hiroshi
Deparment Of Physics Kyushu University
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GOTO Hiroshi
Department of Anesthesiology, University of Kansas Medical Center
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TONOOKA Mayumi
Department of Anesthesiology, University of Kansas Medical Center
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