Comparative studies on rat primary cultured and isolated hepatocytes in the evaluation of a therapeutic agents for liver disease.
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概要
- 論文の詳細を見る
We have investigated the effect of a therapeutic agent for liver disease, Laennec, on the GOT leakage from freshly isolated and primary cultured rat hepatocytes which were treated with CCl<SUB>4</SUB>. By treatment with Laennec together with CCl<SUB>4</SUB>, the GOT leakage from isolated hepatocytes increased and that from cultured hepatocytes decreased, compared to those incubated only with CCl<SUB>4</SUB>. The results suggest that it is better to use primary cultured hepatocytes than to use freshly isolated hepatocytes to evaluate therapeutic agents for liver disease.
- 公益社団法人 日本薬理学会の論文
著者
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Usami Kenichi
Department Of Neurosurgery The University Of Tokyo Hospital
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Kasahara Takako
Department Of Pharmacology School Of Medicine Showa University
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Abe Koichiro
Department Of Cardiovascular Surgery Miki City Hospital
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Sakamoto Koji
Department Of Pharmacology School Of Medicine Showa University
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ABE Koichiro
Department of Plastic and Reconstructive Surgery, Showa University, School of Medicine
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TONOOKA Mayumi
Department of Pharmacology, Showa University, School of Medicine
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TONOOKA Mayumi
Department of Anesthesiology, University of Kansas Medical Center
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