Effect of caerulein with haloperidol on monoamine contents in rat brain regions treated with methamphetamine.
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概要
- 論文の詳細を見る
To elucidate the mechanism of the antiagonistic effect of caerulein on amphetamine-induced hyperactivity, monoamine contents in rat brain regions were measured by HPLC. With a combination of caerulein and haloperidol, dopamine contents in methamphetamine treated-rats were significantly decreased in the striatum. Noradrenaline contents were significantly decreased in the haloperidol-methamphetamine group, but caerulein restored it to the normal levels. Serotonin contents did not change in any of the groups tested. These results may indicate that caerulein acts as a neuromodulator in rat brain and causes suppression of hyperactivity induced by metamphetamine.
- 公益社団法人 日本薬理学会の論文
著者
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Oguchi Katsuji
Department Of Pharmacology School Of Medicine Showa University
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Yasuhara Hajime
Department Of Neonatal Intensive Care Unit Nara Prefectural Hospital
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HASHIMOTO Miyuki
Department of Pharmacology, School of Medicine, Showa University
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HIRAI Takafumi
Department of Pharmacology, School of Medicine, Showa University
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