Antipyrine metabolism in female Lewis and Dark Agouti strains of rats, which are extensive and poor metabolizers of debrisoquine, respectively.
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概要
- 論文の詳細を見る
The metabolism of antipyrine (AP) was investigated in female rats of the Dark Agouti (DA) and Lewis (L) strains, which have been proposed as models for human poor and extensive metabolizers of debrisoquine (DB), respectively. Following i.p. injection of 50 mg/kg of AP, the rate of production of 4-hydroxy-antipyrine in 24-hr urine was increased significantly in the L strain. The results suggested that different cytochrome P-450 isozymes were responsible for hydroxylation of AP and DB and showed interphenotype differences between the two strains.
- 公益社団法人 日本薬理学会の論文
著者
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Oguchi Katsuji
Department Of Pharmacology School Of Medicine Showa University
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Tanaka Einosuke
Institute Of Community Medicine And Institute Of Clinical Medicine University Of Tsukuba
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Kobayashi Shinichi
Department Of Biomedical Engineering Graduate School Of Medicine University Of Tokyo
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Uchida Eiji
Department Of Cardiology Seirei Yokohama General Hospital
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Yasuhara Hajime
Department Of Neonatal Intensive Care Unit Nara Prefectural Hospital
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UCHIDA Eiji
Department of Pharmacology, School of Medicine, Showa University
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