Identification and Expression of Frizzled-3 Protein in Rat Frontal Cortex After Antidepressant and Electroconvulsive Treatment
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概要
- 論文の詳細を見る
The biological basis for the therapeutic mechanisms of depression are still unknown. While performing EST (expressed sequence tag) analysis to identify some molecular machinery responsible for the antidepressant effect, we determined the full-length nucleotide sequence of rat frizzled-3 protein (Frz3) cDNA. Interestingly, Northern blot analysis demonstrated that elevated levels of Frz3 were expressed continually from embryonic day 20.5 to postnatal 4 weeks in developing rat brain. In adult rat brain, Frz3 mRNA was expressed predominantly in the cerebral cortex and hypothalamus and moderately in the hippocampus. Using real-time quantitative PCR, we demonstrated that chronic treatment with two different classes of antidepressants, imipramine and sertraline, reduced Frz3 mRNA expression significantly in rat frontal cortex. Electroconvulsive treatment (ECT) also reduced Frz3 expression. In contrast, antidepressants and ECT failed to reduce Frz2 expression. Additionally, chronic treatment with the antipsychotic drug haloperidol did not affect Frz3 expression. Recently, the Frz/Wingless protein pathway has been proposed to direct a complex behavioral phenomenon. In conclusion, the Frz3-mediated signaling cascade may be a component of the molecular machinery targeted by therapeutics commonly used to treat depression.
- 社団法人 日本薬理学会の論文
- 2005-11-20
著者
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OHATA Hisayuki
Department of Pharmacology, School of Pharmaceutical Sciences, Showa University
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Honda Kazuo
Department of Pharmacology, School of Pharmacy, Showa University, Japan
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Yamada Mitsuhiko
Department of Molecular Pharmacology, Shinshu University School of Medicine
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TAKAHASHI Kou
Department of Psychogeriatrics, National Institute of Mental Health, National Center of Neurology an
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YAMADA Misa
Department of Psychogeriatrics, National Institute of Mental Health, National Center of Neurology an
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Yamada Mitsuhiko
Department Of Psychogeriatrics National Institute Of Mental Health National Center Of Neurology And
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Yamada Misa
Department Of Psychogeriatrics National Institute Of Mental Health National Center Of Neurology And
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Takahashi Kou
Department Of Psychogeriatrics National Institute Of Mental Health National Center Of Neurology And
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Takahashi Kou
Department Of Applied And Environmental Chemistry Kitami Institute Of Technology
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Ohata Hisayuki
Department Of Pharmacology School Of Pharmaceutical Sciences Showa University
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Honda Kazuo
Department Of Pharmacology School Of Pharmaceutical Sciences Showa University
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IWABUCHI Tomoko
Department of Pharmacology, School of Pharmaceutical Sciences, Showa University
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KURAHASHI Chika
Department of Pharmacology, School of Pharmaceutical Sciences, Showa University
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HIGUCHI Teruhiko
Musashi Hospital, National Center of Neurology and Psychiatry
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Kurahashi Chika
Department Of Pharmacology School Of Pharmaceutical Sciences Showa University
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Iwabuchi Tomoko
Department Of Pharmacology School Of Pharmaceutical Sciences Showa University
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Yamada Mitsuhiko
Department Of Molecular Pharmacology Shinshu University School Of Medicine
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Higuchi Teruhiko
Musashi Hospital National Center Of Neurology And Psychiatry
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HONDA Kazuo
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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