Role of Rho-Associated Protein Kinase and Histamine in Lysophosphatidic Acid-Induced Airway Hyperresponsiveness in Guinea Pigs
スポンサーリンク
概要
- 論文の詳細を見る
Inhalation of oleoyl lysophosphatidic acid (LPA) induced airway hyperresponsiveness to acetylcholine (ACh). In contrast, palmitoyl and stearoyl LPA exerted minimal effects. Airway hyperresponsiveness was inhibited by inhalation of Y-27632, an inhibitor of Rho-associated protein kinase (ROCK). Mepyramine, an H1 histamine receptor antagonist and ketotifen, an inhibitor of histamine release and H1 histamine receptor antagonist, also inhibited airway hyperresponsiveness induced by LPA; however, aspirin failed to attenuate this response. The incubation of lung fragments with LPA gave rise to releases in histamine. On the other hand, LPA produced no significant changes on the smooth muscle contraction evoked by ACh. These findings suggest that LPA-induced airway hyperresponsiveness is attributable to activation of the Rho/ROCK-mediated pathway via endothelial cell differentiation gene (EDG) receptors, probably EDG 7. Moreover, histamine release may be involved.
- 社団法人 日本薬理学会の論文
- 2002-03-01
著者
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Fang Yang-il
Department Of Pharmacology School Of Pharmaceutical Sciences Showa University
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HASHIMOTO Terumasa
Department of Pharmacology, School of Pharmaceutical Sciences, Showa University
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NAKANO Yuuki
Department of Pharmacology, School of Pharmaceutical Sciences, Showa University
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YAMASHITA Miyuki
Department of Pharmacology, School of Pharmaceutical Sciences, Showa University
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OHATA Hisayuki
Department of Pharmacology, School of Pharmaceutical Sciences, Showa University
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MOMOSE Kazutaka
Department of Pharmacology, School of Pharmaceutical Sciences, Showa University
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Nakano Yuuki
Department Of Pharmacology School Of Pharmaceutical Sciences Showa University
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Nakano Yuuki
Department Of Electronics Information And Communication Engineering Waseda University
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Ohata H
Department Of Pharmacology School Of Pharmaceutical Sciences Showa University
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Ohata Hisayuki
Department Of Pharmacology School Of Pharmaceutical Sciences Showa University
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Momose Kazutaka
Department Of Pharmacology School Of Pharmaceutical Sciences Showa University
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Momose Kazutaka
Department Of Phamacology School Of Pharmaceutical Sciences Showa University
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Yamashita M
Department Of Pharmacology School Of Pharmaceutical Sciences Showa University
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Yamashita Miyuki
Department Of Applied Biological Chemistry Faculty Of Agriculture Niigata University
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Hashimoto Terumasa
Department Of Pharmacology School Of Pharmacy Shawa University
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