A case of calcifying odontogenic cyst with numerous calcifications: immunohistochemical analysis

概要

論文の詳細を見る
The purpose of this study was to investigate a case of calcifying odontogenic cyst (COG) in which numerous calcifications were observed not only in the lining epithelium, but also in the cyst wall, using cytokeratms 13 (CK13), 19 (CK19), and core binding factor a-1 (cbfa-1) as primary antibodies Cells of Malassez's epithelial rest were stained as controls Cells of the epithelial nests in the cyst wall were reactive for CK13, but their CK19 staining was similar to that observed in the lining epithelial cells Calcifying nodules were reactive only for CK13 Cells of Malassez's epithelial rest were reactive for CK19 but not for CK13 Cbfa-1 positive reactivity was observed only in nuclei of spindle cells in the penodontal ligament CK13 was positive superficial to the prickle cells CK19 was positive in the basal cells of the oral mucosa In the lining epithelium of the cyst, the expressions of CK13 and CK19 were similar to their immunoreactions in the oral mucosa These results suggest that the odontogenic epithelium differentiated into squamous epithelial cells, which began as ghost cells in the COG, and that this process depended on the dystrophic calcification of differentiated odontogenic epithelial cells, not of osteogemc cells
東京歯科大学の論文