Bone formation in titanium porous scaffold with immobilization of BMP-2
スポンサーリンク
概要
- 論文の詳細を見る
Objectives. Bone defects make up a significant clinical problem. The purpose of the present study was to evaluate the osteogenic tissue behavior in a titanium (Ti) porous scaffold with immobilization of bone morphogenetic protein (BMP)-2 in vivo. Methods. Ti scaffold (pore size: 200-500μm) with or without BMP-2 immobilization was implanted into a created defect of a rat femur. Results. One week after implantation, only bone marrow cells were present around the scaffold without BMP, but new bone formation could be observed around the scaffold with BMP. Two weeks after implantation, new bone tissue had formed around the scaffold with and without BMP-2 immobilization. Conclusions. Ti porous scaffold with BMP-2 immobilization can manufacture new bone tissue at an early stage, and can be a beneficial in the repair of bone defects.
- 日本再生歯科医学会の論文
- 2005-03-30
著者
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YOSHINARI Masao
Department of Dental Materials Science, Tokyo Dental College
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INOUE Takashi
Department of Neurosurgery, School of Medicine, Iwate Medical University
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Sato Masaaki
Department Of Dental Science Institute Of Personalized Medical Science Health Sciences University Of
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Mabuchi Mamoru
Department Of Energy Science And Technology Graduate School Of Energy Science Kyoto University
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Saitoh M
Department Of Dental Science Institute Of Personalized Medical Science Health Sciences University Of
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INOUE Takashi
Oral Health Science Center, Tokyo Dental College
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SHIMONO Masaki
Department of Pathology, Tokyo Dental College
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MATSUZAKA Kenichi
Department of Clinical Pathophysiology and Oral Health Science Center
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KOKUBU Eitoyo
Department of Clinical Pathophysiology and Oral Health Science Center
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YAMADA Yasuo
Materials Research Institute for Sustainable Development, National Institute of Advanced Industrial
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Saitoh Masato
Department Of Dental Science Institute Of Personalized Medical Science Health Sciences University Of
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Inoue T
Department Of Pathophysiology Tokyo Dental College
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Shimono Masaki
Department Of Biosphere Science Faculty Of Science Toyama University
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Mabuchi Mamoru
Department Of Energy Science & Technology Graduate School Of Energy Science Kyoto University
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Shimono Masaki
Pathology Tokyo Dental College
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Yoshinari Masao
Oral Health Science Center Hrc7 Tokyo Dental College:department Of Dental Materials Science Tokyo De
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Yoshinari Masao
Department Of Dental Materials Science And Oral Health Science Center Tokyo Dental College
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Matsuzaka Kenichi
Oral Health Science Center Hrc7 Tokyo Dental College:department Of Clinical Pathophysiology Tokyo De
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Yoshinari M
Department Of Dental Materials Science And Oral Health Science Center Tokyo Dental College
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Shintani Masuro
Laboratory Of Brain Research Oral Health Science Center Tokyo Dental College
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Yamada Yasuo
Materials Research Institute For Sustainable Development National Institute Of Advanced Industrial S
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Yoshinari M
Oral Health Science Center Tokyo Dental College
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Inoue Takashi
Department Of Neurosurgery Iwate Medical University
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Inoue Takashi
Department Of Agricultural Engineering Faculty Of Agriculture Hokkaido University
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INOUE Takashi
Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
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