A Novel Embolic Model of Cerebral Infarction and Evaluation of Stachybotrys microspora Triprenyl Phenol-7 (SMTP-7), a Novel Fungal Triprenyl Phenol Metabolite
スポンサーリンク
概要
- 論文の詳細を見る
The aim of the present study was to establish a novel embolic model of cerebral infarction and to evaluate the effect of Stachybotrys microspora triprenyl phenol-7 (SMTP-7), a novel fungal triprenyl phenol metabolite. Thrombotic occlusion was induced by transfer of acetic acid–induced embolus into the brain. The regional cerebral blood flow was measured by a laser Doppler flowmeter to check the ischemic condition. Infarction area was assessed by 2% 2,3,5-triphenyltetrazolium chloride (TTC) staining. Neurological scores were determined by a modified version of the method described by Longa et al. Emboli were accumulated at the temporal or parietal region of the middle cerebral artery. Additionally, we found that this model showed decreased cerebral blood flow and increased infarction area and neurological scores. Treatment with tissue plasminogen activator (t-PA) reduced infarction area and the neurological scores in a dose-dependent manner; moreover, the decreased cerebral blood flow recovered. SMTP-7 also reduced these values. The therapeutic time window of SMTP-7 was longer than that of t-PA. These results indicate that this model may be useful for understanding the pathophysiological mechanisms of cerebral infarction and evaluating the effects of therapeutic agents. Additionally, SMTP-7 is a promising approach to extend the therapeutic time window. Therefore, this novel compound may represent a novel approach for the treatment of cerebral infarction.
著者
-
Hasumi Keiji
Department of Applied Biological Science, Tokyo University of Agriculture and Technology
-
HASHIMOTO Terumasa
Department of Pharmacology, School of Pharmaceutical Sciences, Showa University
-
Shibata Keita
Department of Pharmacology, School of Pharmacy, Showa University, Japan
-
Nobe Koji
Department of Pharmacology, School of Pharmacy, Showa University, Japan
-
Honda Kazuo
Department of Pharmacology, School of Pharmacy, Showa University, Japan
-
Nobe Koji
Department Of Phamacology School Of Pharmaceutical Sciences Showa University
-
Hasumi Keiji
Department Of Agricultural Chemistry Tokyo Noko University
-
Honda Kazuo
Department Of Pharmacology School Of Pharmaceutical Sciences Showa University
-
Shibata Keita
Department Of Pharmacology School Of Pharmacy Shawa University
-
Nobe Koji
Department Of Pharmacology School Of Pharmacy Shawa University
関連論文
- Purpurin as a Specific Inhibitor of Spermidine-Induced Autoactivation of the Protease Plasma Hyaluronan-Binding Protein
- A Novel Embolic Model of Cerebral Infarction and Evaluation of Stachybotrys microspora Triprenyl Phenol-7 (SMTP-7), a Novel Fungal Triprenyl Phenol Metabolite
- Role of Rho-Associated Protein Kinase and Histamine in Lysophosphatidic Acid-Induced Airway Hyperresponsiveness in Guinea Pigs
- Inhibition of Glucan Synthesis by Casein Polymers Crosslinked by Glutaraldehyde
- Inhibition of Glucan Synthesis by Flavipin-crosslinked Casein Polymers
- Chemical and Functional Properties of Mutastein, an Inhibitor of Insoluble Glucan Synthesis by Streptococcus sobrinus
- Isolation and Absolute Configuration of SMTP-0, a Simplest Congener of the SMTP Family Nonlysine-analog Plasminogen Modulators
- High-Glucose Enhances a Thromboxane A_2-Induced Aortic Contraction Mediated by an Alteration of Phosphatidylinositol Turnover
- Inhibition of Acyl-CoA:Cholesterol Acyltransferase by Isohalobacillin, a Complex of Novel Cyclic Acylpeptides Produced by Bacillus sp.A1238
- Inhibition of the Binding of Oxidized Low Density Lipoprotein to the Macrophages by Iturin C-related Compounds
- SMTP-4D, -5D, -6D, -7D and -8D, a New Series of the Non-lysine-analog Plasminogen Modulators with a D-Amino Acid Moiety
- Role of Rho-Associated Protein Kinase and Histamine in Lysophosphatidic Acid-Induced Airway Hyperresponsiveness in Guinea Pigs
- Thrombin-Induced Force Development in Vascular Endothelial Cells : Contribution to Alteration of Permeability Mediated by Calcium-Dependent and -Independent Pathways
- Caspase Cascade Proceeds Rapidly After Cytochrome c Release From Mitochondria in Tumor Necrosis Factor-α-Induced Cell Death
- Simultaneous Real-Time Detection of Initiator- and Effector-Caspase Activation by Double Fluorescence Resonance Energy Transfer Analysis
- Inhibition of Plasminogen Activator Inhibitor-1 by 11-Keto-9(E), 12(E)-octadecadienoic Acid, a Novel Fatty Acid Produced by Trichoderma sp.
- 11-Keto-9(E), 12(E)-octadecadienoic Acid, a Novel Fatty Acid that Enhances Fibrinolytic Activity of Endothelial Cells
- Inhibitors of Autoactivation of Plasma Hyaluronan-Binding Protein (Factor VII Activating Protease)
- Inhibition of Plasma Hyaluronan-Binding Protein Autoactivation by Laccaic Acid
- PMCA, SERCA and Na, K ATPase Alpha Isoforms and Ca^ Homeostasis in Smooth Muscle : Evidence from Gene-Altered Mice
- Comparative Study of Calcium Ion Dynamics and Contractile Response in Rat Middle Cerebral and Basilar Arteries
- Lysophosphatidic Acid (LPA) Induces Plasma Exudation and Histamine Release in Mice via LPA Receptors
- Lysophosphatidic Acid Enhances In Vivo Infiltration and Activation of Guinea Pig Eosinophils and Neutrophils via a Rho/Rho-Associated Protein Kinase-Mediated Pathway
- Identification and Expression of Frizzled-3 Protein in Rat Frontal Cortex After Antidepressant and Electroconvulsive Treatment
- Selective Production of Staplabin and SMTPs in Cultures of Stachybotrys microspora Fed with Precursor Amines
- Activation of Fibrinolysis by SMTP-7 and -8, Novel Staplabin Analogs with a Pseudosymmetric Structure
- Antibiotic A10255(Thioplabin) Enhances Fibrin Binding and Activation of Plasminogen
- EFFECTS OF PHENTOLAMINE MESYLATE AND PROPRANOLOL HYDROCHLORIDE ON ASPIRIN-INDUCED GASTRIC LESIONS AND GASTRIC SECRETION IN THE RAT
- Stachybotrydial Selectively Enhances Fibrin Binding and Activation of Glu-plasminogen
- Enhancement of Fibrinolytic Activity of Vascular Endothelial Cells by Chaetoglobosin A, Crinipellin B, Geodin and Triticone B
- Isolation, Characterization and Biological Activities of Novel Triprenyl Phenols as Pancreatic Cholesterol Esterase Inhibitors Produced by Stachybotrys sp.F-1839
- Inhibition of Plasma Hyaluronan-Binding Protein Autoactivation by Laccaic Acid
- Productivity of Monacolin K(Mevinolin)in the Genous Monascus.
- Isolation of SMTP-3, 4, 5 and -6, Novel Analogs of Staplabin, and Their Effects on Plasminogen Activation and Fibrinolysis
- Isolation of Plactins A, B, C and D, Novel Cyclic Pentapeptides that Stimulate Cellular Fibrinolytic Activity
- SMTP-1 and -2, Novel Analogs of Staplabin Produced by Stachybotrys microspora IFO30018
- Clonostachin, a Novel Peptaibol That Inhibits Platelet Aggregation
- Staplabin, a Novel Fungal Triprenyl Phenol which Stimulates the Binding of Plasminogen to Fibrin and U937 Cells
- Induction of Neuroserpin Expression in Rat Frontal Cortex after Chronic Antidepressant Treatment and Electroconvulsive Treatment
- Role of inflammatory cytokines in liver surgery and therapeutic trials for controlling surgical stress by protease inhibitor and Bcl-xL gene transfer to the hepatocyte
- Microbial Conversion of L-Ascorbic Acid to L-Erythroascorbic Acid
- Glucosyldiacylglycerol Enhances Reciprocal Activation of Prourokinase and Plasminogen
- Enhancement of Fibrinolytic Activity of U937 Cells by Malformin A_1
- Enhancement of Reciprocal Activation of Prourokinase and Plasminogen by the Bacterial Lipopeptide Surfactins and Iturin Cs
- A Novel Embolic Model of Cerebral Infarction and Evaluation of Stachybotrys microspora Triprenyl Phenol-7 (SMTP-7), a Novel Fungal Triprenyl Phenol Metabolite
- Elucidation of Crucial Structures for a Catechol-Based Inhibitor of Plasma Hyaluronan-Binding Protein (Factor VII Activating Protease) Autoactivation
- Promoting effects of carminic acid-enriched cochineal extracts on capsular invasive thyroid carcinomas through targeting activation of angiogenesis in rats
- A new series of the SMTP plasminogen modulator with a phenylglycine-based side chain
- Structure-activity relationships of 11 new congeners of the SMTP plasminogen modulator
- Fibrinolytic Activation Promoted by the Cyclopentapeptide Malformin: Involvement of Cytoskeletal Reorganization
- A new series of the SMTP plasminogen modulators with a phenylamine-based side chain
- Pre-SMTP, a key precursor for the biosynthesis of the SMTP plasminogen modulators