Glucosyldiacylglycerol Enhances Reciprocal Activation of Prourokinase and Plasminogen

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概要

• 論文の詳細を見る

• Reciprocal activation of prourokinase (pro-u-PA) and plasminogen is an important mechanism in the initiation and propagation of local fibrinolytic activity. We found that glucosyldiacylglycerol (GDG) enhanced the reciprocal activation by 1.5- to 2-fold at 0.7–16 μM, accompanying increased conversions of both zymogens to active two-chain forms. The reciprocal activation system consists of (i) plasminogen activation by pro-u-PA to form plasmin, (ii) pro-u-PA activation by the resulting plasmin to form two-chain u-PA (tcu-PA), and (iii) plasminogen activation by the resulting tcu-PA. Whereas GDG minimally affected steps (ii) and (iii) in isolated systems, it markedly enhanced step (i) in the absence of the conversion of pro-u-PA to tcu-PA. GDG significantly increased the intrinsic fluorescence of pro-u-PA (6.7%), but not that of tcu-PA or plasminogen. The large change in intrinsic fluorescence suggests that GDG selectively affects pro-u-PA to alter its conformation, and this mechanism may account for enhancement of its intrinsic plasminogen activator activity.

• 社団法人 日本農芸化学会の論文
• 2004-07-23

著者

• Hasumi Keiji

  Department Of Applied Biological Science Tokyo Noko University

• Hasumi Keiji

  Department Of Agricultural Chemistry Tokyo Noko University

• Maeda Fumihiko

  Department Of Applied Biological Science Tokyo Noko University

• Hasumi Keiji

  Dep. Of Applied Biological Sci. Tokyo Univ. Of Agriculture And Technol.

• Narasaki Ritsuko

  Department Of Applied Biological Science Tokyo Noko University

• Wu Wenhui

  Dep. Of Applied Biological Sci. Tokyo Univ. Of Agriculture And Technol.

• Wu Wenhui

  Department Of Applied Biological Science Tokyo University Of Agriculture And Technology

• HASUMI Keiji

  Department of Applied Biological Science, Tokyo Noko University

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