Elucidation of Crucial Structures for a Catechol-Based Inhibitor of Plasma Hyaluronan-Binding Protein (Factor VII Activating Protease) Autoactivation
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概要
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Plasma hyaluronan-binding protein (PHBP) is a serine protease the activation of which is implicated in inflammation. Previous investigations have suggested the presence of catechol-binding sites in its proenzyme form, pro-PHBP. Here we found that compounds with plural catechol groups conjugated with strong electron-withdrawing groups, such as tyrphostin AG 537 (IC50=18 nM), were potent inhibitors of pro-PHBP activation.
- 2011-10-23
著者
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Yamamoto Eisaku
Department of Applied Biological Science, Tokyo University of Agriculture and Technology
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Kitano Yoshikazu
Department Of Applied Biological Science Tokyo Noko University
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Hasumi Keiji
Department Of Agricultural Chemistry Tokyo Noko University
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Hasumi Keiji
Department Of Applied Biological Science Tokyo University Of Agriculture And Technology
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Kitano Yoshikazu
Department Of Applied Biological Science Tokyo University Of Agriculture And Technology
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Yamamoto Eisaku
Department Of Applied Biological Science Tokyo University Of Agriculture And Technology
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