Inhibition of Plasma Hyaluronan-Binding Protein Autoactivation by Laccaic Acid
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概要
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Plasma hyaluronan-binding protein (PHBP) is a serine protease implicated in proteolysis under inflammatory conditions. We identified laccaic acid, a widely used food coloring from scale insects, as a potent inhibitor of the protease in terms of both autoactivation of the PHBP proenzyme (IC50 = 0.35–0.55 μg/ml) and the catalytic activity of the active enzyme (IC50 = 1.1 μg/ml).
著者
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Nishimura Naoko
Department of Applied Biological Science, Tokyo University of Agriculture and Technology
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Takai Masayuki
Department of Applied Biological Science, Tokyo University of Agriculture and Technology
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Hasumi Keiji
Department of Applied Biological Science, Tokyo University of Agriculture and Technology
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SEKIDO Chikako
Department of Applied Biological Science, Tokyo University of Agriculture and Technology
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