Riluzole Does Not Affect Hippocampal Synaptic Plasticity and Spatial Memory, Which Are Impaired by Diazepam in Rats
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概要
- 論文の詳細を見る
We have previously demonstrated that riluzole has anxiolytic-like effects in rats, without affecting spontaneous alternation performance in the Y-maze test. However, the effects of riluzole on hippocampal synaptic plasticity were still unclear. In this study, we showed that bath application of riluzole did not impair long-term potentiation and long-term depression, whereas a benzodiazepine anxiolytic, diazepam, significantly impaired them. Furthermore, the acquisition of spatial memory in the Morris water maze test was impaired in diazepam-treated but not riluzole-treated rats. We thus provide further evidence for the potential usefulness of riluzole as an anxiolytic that does not cause amnesia.
- 公益社団法人 日本薬理学会の論文
著者
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Oka Jun-ichiro
Laboratory Of Pharmacology Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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Yamada Mitsuhiko
Department Of Molecular Pharmacology Shinshu University School Of Medicine
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Iijima Takahiro
Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Japan
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Saitoh Akiyoshi
Department of Neuropsychopharmacology, National Institute of Mental Health National Center of Neurology and Psychiatry, Japan
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Yamada Mitsuhiko
Department of Neuropsychopharmacology, National Institute of Mental Health National Center of Neurology and Psychiatry, Japan
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Inagaki Masatoshi
Department of Neuropsychopharmacology, National Institute of Mental Health National Center of Neurology and Psychiatry, Japan
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Sasaki-Hamada Sachie
Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Japan
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Sacai Hiroaki
Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Japan
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Sugiyama Azusa
Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Japan
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