Effects of Tamoxifen on <sc>L</sc>-Glutamate Transporters of Astrocytes
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概要
- 論文の詳細を見る
Tamoxifen (Tam) decreased the clearance of <sc><font size = "-2">L</font></sc>-glutamate (<sc><font size = "-2">L</font></sc>-Glu) by cultured astrocytes at 1 pM, 1 nM, and 1 μM, but became toxic at 10 μM. When <sc><font size = "-2">L</font></sc>-Glu transporters were mostly inhibited by threo-β-benzyloxyaspartate (TBOA) (1 mM) or <sc><font size = "-2">D</font></sc>,<sc><font size = "-2">L</font></sc>-threo-β-hydroxyaspartate (THA) (1 mM), Tam (1 nM) did not change extracellular <sc><font size = "-2">L</font></sc>-Glu concentration, confirming that Tam attenuates <sc><font size = "-2">L</font></sc>-Glu transport through <sc><font size = "-2">L</font></sc>-Glu transporters. ICI182,780, LY294002, and U0126 inhibited the effect of Tam dose-dependently, suggesting the involvement of estrogen receptors (ERs), the phosphatidylinositol 3-kinase (PI3K) cascade, and the mitogen-activated protein kinase (MAPK) cascade in the effect of Tam.
- 公益社団法人 日本薬理学会の論文
著者
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Nakazawa Ken
Division Of Pharmacology National Institute Of Health Sciences
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Oka Jun-ichiro
Laboratory Of Pharmacology Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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Sato Kaoru
Division Of Chemistry Graduate School Of Science Hokkaido University
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Ohwada Tomohiko
Laboratory Of Organic And Medicinal Chemistry Graduate School Of Pharmaceutical Sciences University
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Saito Yoshihiko
Division Of Cardiovascular Medicine Kumamoto University Graduate School Of Medical Sciences
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Saito Yoshihiko
Division of Pharmacology, National Institute of Health Sciences, Japan
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Sato Kaoru
Division of Pharmacology, National Institute of Health Sciences, Japan
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