Block by Phytoestrogens of Recombinant Human Neuronal Nicotinic Receptors
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概要
- 論文の詳細を見る
The effects of phytoestrogens on neuronal nicotinic acetylcholine receptor/channels were examined by expressing recombinant channels in Xenopus oocytes. When functional channels were expressed with human α4 and β2 subuints, daidzein (10 and 100 μM) partially inhibited the ionic current activated by acetylcholine. The current inhibition was also observed when functional channels were expressed with human α3 and β4 subunits or rat homologues. Genistin (100 μM) also inhibited the acetylcholine-activated current. Tamoxifen (100 μM), an antiestrogen did not antagonize the inhibition by daidzein. The results suggest that phytoestrogens, like estrogens and xenoestrogens, block human neuronal acetylcholine receptors through non-genomic mechanisms.
- 社団法人 日本薬理学会の論文
- 2003-09-01
著者
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NAKAZAWA Ken
Division of Pharmacology, National Institute of Health Sciences
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Nakazawa Ken
Division Of Pharmacology National Institute Of Health Sciences
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Ohno Yasuo
Division Of Internal Medicine And Thoracic Oncology National Cancer Center Hospital
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