Effect of Flunarizine on Arterial Thrombosis after Endarterectomy in Rats
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概要
- 論文の詳細を見る
Unilateral carotid endarterectomy was performed microsurgically in 60 rats. The effects of perioperative administration of aspirin and flunarizine, a Ca^<2+> entry blocker, on thrombus formation were examined 24 hours after endarterectomy. An untreated group of endarterectomized rats served as controls. Platelet adhesion, blood cells, and fibrin cords were observed at the cut edge of the intima as well as in the endarterectomized area in all three groups. However, these findings were significantly more extensive in the control group than in the drug-treated groups. Flunarizine was as effective as aspirin in inhibiting platelet adhesion and fibrin cord formation. Both drugs significantly increased the patency rate after carotid endarterectomy.
- 日本脳神経外科学会の論文
- 1989-07-15
著者
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KAWANO Hirokazu
Department of Neurosurgery, Miyazaki Prefectural Hospital
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KOBAYASHI Shinjiro
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokuriku University
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HAYASHI Minoru
Department of Materials Science and Engineering, Nagoya Institute of Technology
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Hayashi Minoru
Department Of Neurosurgery Fukui Medical School
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Kawano Hirokazu
Department Of Neurosurgery Fukui Medical School
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Kabuto Masanori
Department Of Neurosurgery Fukui Medical School
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Handa Yuji
Department of Neurosurgery, Fukui Medical University
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Kobayashi Shinjiro
Department Of Chemical Pharmacology Toyama Medical And Pharmaceutical University
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Handa Yuji
Division Of Neurosurgery Department Of Sensory & Locomotor Medicine Faculty Of Medical Science U
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Handa Yuji
Department Of Neurosurgery Fukui Medical School
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KOBAYASHI Hidenori
Department of Neurosurgery, Fukui Medical School
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Kobayashi Hidenori
Department Of Neurosurgery Fukui Medical School
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Kobayashi Hidenori
Department Of Civil Engineering Saitama University
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Hayashi Minoru
Department Of Applied Chemistry Faculty Of Engineering Ehime University
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Handa Yuji
Division Of Neurosurgery Department Of Sensory & Locomotor Medicine Faculty Of Medical Science U
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Kobayashi Hidenori
Department Of Brain And Nerve Science Oita Medical University
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KAWANO Hirokazu
Department of Neurosurgery, Fukui Medical School
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Kobayashi Shinjiro
Department of Applied Chemistry, Faculty of Engineering, Kyushu University
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