High Titer Retroviral Gene Transduction to Neural Progenitor Cells for Establishment of Donor Cells for Neural Transplantation to Parkinsonian Model Rats
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概要
- 論文の詳細を見る
Neural progenitor cells (NPCs) are expected to be useful donor sources for cell transplantation therapy in Parkinson's disease. However, control of the differentiational lineage, especially into dopaminergic neurons, is still difficult. Thus, genetic modification of NPCs to produce l-dopa is potentially useful. The present study prepared high titer retrovirus carrying human tyrosine hydroxylase-1 (HTH-1) gene. HTH-1 gene could be efficiently transduced into NPCs obtained from the E12.5 rat mesencephalon. This retroviral gene transduction caused no apparent changes in survival, proliferation, or differentiation. In vitro, HTH-1 gene-transduced NPCs released little l-dopa and addition of tetrahydrobiopterin, the cofactor of tyrosine hydroxylase, was required for production of l-dopa. In vivo, three of seven hemiparkinsonian model rats that received HTH-1 gene-transduced donor NPCs achieved functional recovery. High titer retroviral vector for gene transduction could be used to prepare NPCs for transplantation to hemi-parkinsonian model rats. However, functional recovery after transplantation of HTH-1 gene-transduced NPCs was incomplete.
- 日本脳神経外科学会の論文
- 2004-07-15
著者
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Date Isao
Department Of Neurological Surgery Okayama Graduate School Of Medicine And Dentistry
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ISONO Mitsuo
Department of Neurosurgery, Oita Medical University
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NISHINO Hitoo
Department of Physiology, Nagoya City University Medical School
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KOBAYASHI Hidenori
Department of Neurosurgery, Fukui Medical School
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Kobayashi Hidenori
Department Of Civil Engineering Saitama University
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Baba Hiroko
Department Of Molecular Neurobiology Tokyo University Of Pharmacy And Life Science
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Isono Mitsuo
Department Of Brain And Nerve Science Oita Medical University
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Nishino Hitoo
Department Of Neuro-physiology And Brain Science Nagoya City University Graduate School Of Medical S
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KODAMA Yuji
Department of Mathematics,Clarkson College of Technology
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HlDA Hideki
Department of Neuro-physiology and Brain Science, Nagoya City University Graduate School of Medical
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JUNG Cha-Gyun
Department of Neuro-physiology and Brain Science, Nagoya City University Graduate School of Medical
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Kobayashi Hidenori
Department Of Neurosurgery Oita University Faculty Of Medicine
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Kodama Yuji
Department Of Mathematics Clarkson College Of Technology
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Hlda Hideki
Department Of Neuro-physiology And Brain Science Nagoya City University Graduate School Of Medical S
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Jung Cha-gyun
Department Of Neuro-physiology And Brain Science Nagoya City University Graduate School Of Medical S
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Kodama Yuji
Department Of Neurosurgery Oita University Faculty Of Medicine
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Kobayashi Hidenori
Department Of Brain And Nerve Science Oita Medical University
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Yamada Kazuo
Department Of Architecture Faculty Of Engineering Aichi Institute Of Technoligy
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Kodama Yuji
Department Of Electrical Engineering Faculty Of Engineering Science Osaka University
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Jung Cha-Gyun
Department of Alzheimer's Disease Research, Research Institute, National Center for Geriatrics and Gerontology (NCGG)
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Yamada Kazuo
Department of Applied Molecular Chemistry, College of Industrial Technology, Nihon University
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