STUDIES ON THE PHYSICAL DEPENDENCE LIABILITY OF ANALGESICS:lST REPORT : ELECTRON MICROSCOPIC STUDIES ON THE ULTRASTRUCTURAL TRANSFORMATION OF MITOCHONDRIA IN THE CELLS OF ZONA FASCICULATA OF THE ADRENAL CORTEX IN MORPHINE ADDICTED RATS
スポンサーリンク
概要
- 論文の詳細を見る
Influence of morphine on the fine structure of mitochondria in the cells of zona fasciculata in rat adrena 1 cortex was studied electronmicroscopically. By the administration of morphine to rats in a dose of 20 mg/kg, the specific honeycomb like structure of mitochondria in adrenocortical cells was observed to be transformed from vesicular forms into tubulo-vescicular or tubular ones, while the changed structure gradually diminished during repeated administration of the drug. Withdrawal of morphine caused an extensive re-transformation, while with a reinjection of the drug, a prompt restoration to the pretreated structure was observed. The feasibility of utilizing this transformation as an index of physical dependence liability has been discussed.
- 公益社団法人 日本薬理学会の論文
著者
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Yano Ichiro
Department Of Pediatrics Daisan Hospital Jikei University School Of Medicine
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Nishino Hitoo
Department Of Neuro-physiology And Brain Science Nagoya City University Graduate School Of Medical S
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Yamamoto Hiroyuki
Department Of Applied Biology Faculty Of Textile Science And Technology Shinshu University
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MURANO Tadashi
Department of Pharmacology, Wakayama Aledical College
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YAMAMOTO Hiroyuki
Department of Pharmacology, Wakayama Medical College
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MURANO TADASHI
Department of Pharmacology, Osaka City University Medical School
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