POTENTIATING EFFECT OF COENZYME Q ON ROOT POTENTIALS OF PERFUSED FROGS SPINAL CORD
スポンサーリンク
概要
- 論文の詳細を見る
One of the biologically active quinones, coenzyme Q (CoQ), is widely distributed in nature and primarily localized in the mitochondria of animal cells (1, 2). There is considerable evidence to support the fact that CoQ may be an important carrier for mediating between flavoprotein and cytochrome chains in mitochondria (3, 4).<BR> On the other hand, there is considerable literature on the pharmacologic action of exogenous CoQ (5, 6), however, reports investigating structure-activity relationship, e.g. relationships between the activity and the polyisoprenoid side chains or the quinone ring, etc. are few. The mechanism of action of CoQ also has not been ascertained. To clarify these points, effect of CoQ on the root potentials of perfused frogs spinal cord was investigated.
- 社団法人 日本薬理学会の論文
著者
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Nishino Hitoo
Department Of Neuro-physiology And Brain Science Nagoya City University Graduate School Of Medical S
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MURANO Tadashi
Department of Pharmacology, Wakayama Medical College
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Masuda Minoru
Department Of Forest And Biomaterials Science Graduate School Of Agriculture Kyoto University
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Yamamoto Hiroyuki
Department Of Applied Biology Faculty Of Textile Science And Technology Shinshu University
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MURANO Tadashi
Department of Pharmacology, Wakayama Aledical College
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YAMAMOTO Hiroyuki
Department of Pharmacology, Wakayama Medical College
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MURANO TADASHI
Department of Pharmacology, Osaka City University Medical School
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