STUDIES ON THE PHYSICAL DEPENDENCE LIABILITY OF ANALGESICS : 4TH REPORT: ELECTRON MICROSCOPIC STUDY ON INTRAMITOCHONDRIAL STRUCTURE OF ZONA FASCICULATA CELLS IN ADRENAL CORTEX IN CODEINE ADDICTED RATS
スポンサーリンク
概要
- 論文の詳細を見る
Influence of codeine on the fine structure of mitochondria in the cells of zona fasciculata of rat adrenal cortex was studied electronmicroscopically. By the administration of codeine in a dose of 40 mg/kg, the number of intramitochondrial vesicles was decreased, the change being diminished during repeated administration of the drug. Withdrawal of codeine reproduced an extensive transformation, while with a re-injection of the drug, a prompt restoration to the pretreated structure was observed. The feasibility of utilizing this transformation as an index of physical dependence liability has been discussed.
- 社団法人 日本薬理学会の論文
著者
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Yamamoto Hiroyuki
Department of Cardiology, Kurashiki Central Hospital
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MASUDA Yasusuke
Department of Toxicology, Niigata College of Pharmacy
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NISHINO Hitoo
Department of Physiology, Nagoya City University Medical School
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YANO ICHIRO
Department of Pediatrics, Daisan Hospital, Jikei University School of Medicine
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Yano Ichiro
Research Institute For Medical Sciences Wakayama Medical College
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Yano Ichiro
Department Of Pediatrics Daisan Hospital Jikei University School Of Medicine
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Nishino Hitoo
Department Of Neuro-physiology And Brain Science Nagoya City University Graduate School Of Medical S
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MURANO Tadashi
Department of Pharmacology, Wakayama Medical College
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Masuda Yasusuke
Department Of Toxicology Niigata College Of Pharmacy
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Yamamoto Hiroyuki
Department Of Applied Biology Faculty Of Textile Science And Technology Shinshu University
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YANO Ichiro
Department of Pharmacology, Wakayama Medical College
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MURANO Tadashi
Department of Pharmacology, Wakayama Aledical College
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MASUDA Yasusuke
Department of Pharmacology, Wakayama Aledical College
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NISHINO Hitoo
Department of Pharmacology, Wakayama Medical College
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YAMAMOTO Hiroyuki
Department of Pharmacology, Wakayama Medical College
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MURANO TADASHI
Department of Pharmacology, Osaka City University Medical School
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