Pharmacological Differences between Liu-Jun-Zi-Tang, a Traditional Chinese Herbal Medicine, and Domperidone on Isolated Guinea-Pig Ileum(Pharmacology)

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概要

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• The different characteristics of Liu-Jun-Zi-Tang, a spray-dried powdered extract from 8 Chinese herbs, and domperidone, a D2 antagonist, both of which are used clinically for the treatment of gastritis, were validated in isolated guinea pig ileal longitudinal muscle. Liu-Jun-Zi-Tang at 0.05mg/ml did not affect the twitch response by electrical field stimulation, but it concentration-dependently inhibited the twitch response at concentrations of 0.1 and 1.0mg/ml, and maximum inhibition occurred 5min after application of Liu-Jun-Zi-Tang. In the presence of Liu-Jun-Zi-Tang, the concentration-response curve for ACh-contraction showed inhibition in a non-competitive manner, which is the same as domperidone. In the presence of Liu-Jun-Zi-Tang (1.0mg/ml), ACh (10^<-7>M)-, histamine (5×10^<-7>M)- and barium chloride (10^<-4>M)-induced basal contractions were inhibited by 24, 19 and 54%, respectively. On the other hand, in the presence of domperidone (2×10^<-5>M), ACh- and barium chloride-induced basal contractions were inhibited by 28 and 63%, respectively, similar to that in the presence of Liu-Jun-Zi-Tang. However, the inhibition of histamine-induced contraction in the presence of domperidone was significantly increased (81%) compared with that in the presence of Liu-Jun-Zi-Tang. These findings suggest that Liu-Jun-Zi-Tang has milder effects on histamine-induced disorders than domperidone. In other words, domperidone has a more potent effect on histamine-induced disorders.

• 社団法人日本薬学会の論文
• 2006-07-01

著者

• Maeda Takehiko

  Department of Pharmacology, Wakayama Medical University

• Ozaki Masanobu

  Department of Toxicology, Niigata University of Pharmacy and Applied Life Science

• Kishioka Shiroh

  Department of Pharmacology, Wakayama Medical University

• Yamamoto Hiroyuki

  Department of Cardiology, Kurashiki Central Hospital

• NAGATOMO Takafumi

  Department of Pharmacology, Niigata University of Pharmacy and Applied Life Sciences

• Yamamoto Hiroyuki

  Department Of Cardiology Kurashiki Central Hospital

• Ozaki M

  Institute Of Space And Astronautical Science Jaxa

• Ozaki Masanobu

  和歌山県立医科大学 薬理学教室

• Ozaki Masanobu

  Department Of Cardiology Fukuoka University School Of Medicine

• Maeda Takehiko

  Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University

• Nagatomo T

  Dep. Of Pharmacology Fac. Of Pharmaceutical Sciences Niigata Univ. Of Pharmacy And Applied Life Scie

• Ozaki Masanobu

  Institute Of Space And Astronautical Science Jaxa

• Yamashita Hironobu

  Graduate School Of Bioagricultural Science Nagoya University

• Yamamoto H

  Laboratory Of Plant Pathology Department Of Life Sciences Faculty Of Agriculture Kagawa University

• Yamamoto Hiroyuki

  Department Of Gastroenterology Akita Red Cross Hospital

• Ohno Masanori

  Institute Of Space And Astronautical Science Japan Aerospace Exploration Agency

• Nagatomo Takafumi

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And App

• Yamamoto H

  Graduate School Of Bioagricultural Science Nagoya University

• Kishioka Shiroh

  Department Of Pharmacology Wakayama Medical College

• Yamamoto Hiroyuki

  Department Of Applied Biology Faculty Of Textile Science And Technology Shinshu University

• Yamamoto Hiroyuki

  Department Of Pharmacology Wakayama Medical University

• Yamamoto H

  First Department Of Internal Medicine Sapporo Medical University

• Yamamoto Hiroyuki

  Laboratory For Biopolymer Chemistry Department Of Polymer Science And Engineering Kyoto Institute Of

• Namikawa Tomoko

  Biological Res. Dep. Sawai Pharmaceutical Co. Ltd.

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