Activation of Spinal Anti-analgesic System Following Electroacupuncture Stimulation in Rats

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概要

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• We evaluated the interaction between electroacupuncture (EA)-induced antinociception and an endogenous anti-analgesic system. EA was applied to the ST-36 acupoint for 45 min in male Sprague-Dawley rats, and pain thresholds were assessed by the hind-paw pressure test. EA produced a marked increase in pain thresholds and its antinociceptive action was completely reversed by naloxone (5 mg/kg). The analgesic effects of subcutaneous morphine (7 mg/kg) following EA stimulation were significantly attenuated. The attenuation of morphine analgesia was inversely proportional to the time intervals between EA termination and morphine injection, and the effect was not observed 120 min after EA stimulation. The analgesic effects of i.t. morphine (10 μg), but not i.c.v. morphine (25 μg), following EA were also attenuated. On the other hand, systemic morphine (7 mg/kg)-induced hyperthermia was not affected by EA. Moreover, i.c.v. morphine, but not i.t. morphine, produced hyperthermia. The i.c.v. morphine-induced hyperthermia was not affected by EA, similar to i.c.v. morphine analgesia. These results suggest that the attenuation of morphine analgesia following EA, that is, the activation of an endogenous anti-analgesic system, is closely related to the activation of an analgesic system by EA and that the spinal cord plays a critical role in the activation of the endogenous anti-analgesic systems.

• 社団法人 日本薬理学会の論文
• 2005-12-20

著者

• Gao Yuan

  Department of Pharmaceutics, School of Pharmacy, East China University of Science and Technology

• Maeda Takehiko

  Department of Pharmacology, Wakayama Medical University

• Ozaki Masanobu

  Department of Toxicology, Niigata University of Pharmacy and Applied Life Science

• Kishioka Shiroh

  Department of Pharmacology, Wakayama Medical University

• Gao Yuan

  Department Of Pharmacology Wakayama Medical University

• HAMABE Wakako

  Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• Hamabe Wakako

  Department Of Pharmacology Wakayama Medical University

• Hamabe Wakako

  Department Of Clinical Pharmacy Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Ozaki M

  Institute Of Space And Astronautical Science Jaxa

• Ozaki Masanobu

  和歌山県立医科大学 薬理学教室

• Ozaki Masanobu

  Department Of Cardiology Fukuoka University School Of Medicine

• FUKAZAWA Tohji

  Department of Pharmacology, Wakayama Medical University

• KUMAMOTO Kazumasa

  Department of Pharmacology, Wakayama Medical University

• YAMAMOTO Chizuko

  Department of Pharmacology, Wakayama Medical University

• FUKAZAWA Yohji

  Department of Pharmacology, Wakayama Medical University

• Maeda Takehiko

  Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University

• Ozaki Masanobu

  Institute Of Space And Astronautical Science Jaxa

• Ohno Masanori

  Institute Of Space And Astronautical Science Japan Aerospace Exploration Agency

• Fukazawa Tohji

  Department Of Pharmacology Wakayama Medical University

• Kumamoto Kazumasa

  Department Of Pharmacology Wakayama Medical University

• Kishioka Shiroh

  Department Of Pharmacology Wakayama Medical College

• Yamamoto Chizuko

  Department Of Pharmacology Wakayama Medical University

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