Preparation and Characterization of 5-Fluorouracil Loaded Chitosan Microspheres by a Two-Step Solidification Method
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概要
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Chitosan, as a natural biopolymer, has potential applications in controlling the release of drugs due to its unique natural and physiochemical properties. Conventionally, an emulsion crosslinking method was used to prepare chitosan microspheres. In this study, a novel method of preparing 5-fluorouracil-loaded chitosan microspheres was established by combining the emulsification technique and a two-step solidification method using both glutaraldehyde (GTA) and tripolyphosphate (TPP) as crosslinking agents. The microspheres were characterized by surface morphology, encapsulation efficiency, yield of microspheres and drug release profile in vitro. The optimal chitosan microspheres were achieved by crosslinking chitosan with both TPP (0.1%, pH 4.0) and GTA (1.0%, v/v) with span-80 additive under a crosslinking time of 1 h with TPP and GTA, respectively.
著者
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Sun Yi
Department of Pharmaceutics, School of Pharmacy, East China University of Science and Technology
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Gu Lei
Department of Pharmaceutics, School of Pharmacy, East China University of Science and Technology
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Gao Yuan
Department of Pharmaceutics, School of Pharmacy, East China University of Science and Technology
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Gao Feng
Department of Pharmaceutics, School of Pharmacy, East China University of Science and Technology
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Sun Yi
Department Of Analytical Chemistry Shenyang Pharmaceutical University
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Gao Feng
Department Of Civil And Environmental Engineering Northwestern University
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Gao Feng
Department Of Chemistry Fudan Univerisity
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- Preparation and Characterization of 5-Fluorouracil Loaded Chitosan Microspheres by a Two-Step Solidification Method
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