6-Hydroxydopamine Lesion Prevents Induction of Tyrosine Hydroxylase by Haloperidol in the Rat Substantia Nigra, Pars Reticulata.
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the number of tyrosine hydroxylase (TH)-positive neurons in the rat substantia nigra (SN) after unilateral lesion of SN dopamine neurons with intranigral 6-hydroxydopamine (6-OHDA) injection. Non-radioactive in situ hybridization procedure and immunohistochemistry detected much less (<5%) TH-positive neurons in the lesioned SN, compared with the contralateral side. Single administration of a dopamine antagonist haloperidol failed to increase TH labeling on the lesioned side, although it increased that in the contralateral SN pars reticulata (SNr), as in the case of unlesioned animals. These results indicate that 6-OHDA destroyed not only TH-positive SN neurons but also TH-negative but -inducible SNr neurons. It is probable that these "TH inducible" SNr neurons are dopaminergic neurons although they usually do not express TH at detectable levels.
- 日本学士院の論文
著者
-
KUMAZAKI Michiko
Department of Physiology, Nagoya City University Medical School
-
Nishino Hitoo
Department Of Neuro-physiology And Brain Science Nagoya City University Graduate School Of Medical S
-
Obata Kunihiko
Laboratory Of Neurochemistry Department Of Molecular Physiology National Institute For Physiological
-
Kumazaki Michiko
Department Of Anatomy Okayama University
-
STORK Oliver
Laboratory of Neurochemistry, National Institute for Physiological Sciences
関連論文
- Comparison of Exhaled Nitric Oxide and Cardiorespiratory Indices between Nasal and Oral Breathing during Submaximal Exercise in Humans
- Estrogen protects against while testosterone exacerbates vulnerability of the lateral striatal artery to chemical hypoxia by 3-nitropropionic acid
- Acute 3-ntropropionic acid intoxication induces striatal astrocytic cell death and dysfunction of the blood-brain barrier: involvement of dopamine toxicity
- Dopa-producing astrocytes generated by adenoviral transduction of human tyrosine hydroxylase gene: in vitro study and transplantation to hemiparkinsonian model rats
- DEXAMETHASONE ATTENUATES THE EXTRAVASATION OF SERUM PROTEINS AND PREVENTS INFARCTION IN A RAT MODEL OF BRAIN ISCHEMIA-REPERFUSION
- Development of stellate and basket cells and their apoptosis in mouse cerebellar cortex
- Development of GABAergic neurons from the ventricular zone in the superior colliculus of the mouse
- Neurodegeneration of substantia nigra accompanied with macrophage/microglia infiltration after intrastriatal hemorrhage
- Optical imaging reveals cation-Cl^- cotransporter-mediated transient rapid decrease in intracellular Cl^- concentration induced by oxygen-glucose deprivation in rat neocortical slices
- Optical Recording of Propagation of Neuronal Activities in the CA1 Region of the Rat Hippocampus
- Simultaneous optical imaging of intracellular Cl^- in neurons in different layers of rat neocortical slices: advantages and limitations
- SPATIO-TEMPORAL PATTERN OF DYSFUNCTION OF THE BLOOD-BRAIN BARRIER IN THE STRIATUM AFTER SYSTEMIC INTOXICATION WITH 3-NITROPROPIONIC ACID : A MITOCHONDRIAL TOXIN
- Systemic, but not intraparenchymal, administration of 3-nitropropionic acid mimics the neuropathology of Huntington's disease: a speculative explanation
- High Titer Retroviral Gene Transduction to Neural Progenitor Cells for Establishment of Donor Cells for Neural Transplantation to Parkinsonian Model Rats
- STUDIES ON THE PHYSICAL DEPENDENCE LIABILITY OF ANALGESICS : 4TH REPORT: ELECTRON MICROSCOPIC STUDY ON INTRAMITOCHONDRIAL STRUCTURE OF ZONA FASCICULATA CELLS IN ADRENAL CORTEX IN CODEINE ADDICTED RATS
- ANTAGONISM BY NALOXONE OF TOLERANCE AND DEPENDENCE IN MICE GIVEN A SINGLE DOSE OF MORPHINE
- Dopamine metabolism in the striatum of hemiparkinsonian model rats with dopaminergic grafts
- Cloning and Sequence Analysis of cDNA for a Possible DNA- Binding Protein 5E5 in the Nervous System^1
- Development of the GABA system in organotypic culture of hippocampal and cerebellar slices from a 67-kDa isoform of glutamic acid decarboxylase (GAD67)-deficient mice
- GABA and histogenesis in fetal and neonatal mouse brain lacking both the isoforms of glutamic acid decarboxylase
- Development and neural function of glutamic acid decarboxlyase (GAD)-deficient mice
- POTENTIATING EFFECT OF COENZYME Q ON ROOT POTENTIALS OF PERFUSED FROGS SPINAL CORD
- STUDIES ON PHARMACODYNAMIC ACTION OF N-ETHYLMALEIMIDE (NEM):1ST REPORT : INFLUENCE OF NEM ON SYNAPTIC TRANSMISSION OF SYMPATHETIC NERVES IN GUINEA PIGS
- STUDIES ON THE PHYSICAL DEPENDENCE LIABILITY OF ANALGESICS:3RD REPORT : ELECTRON MICROSCOPIC STUDY ON INTRAMITOCHONDRIAL STRUCTURE OF ZONA FASCICULATA CELLS IN ADRENAL CORTEX IN A NEW ANALGESIC, CG-315 CHRONICALLY ADMINISTERED RATS
- STUDIES ON THE PHYSICAL DEPENDENCE LIABILITY OF ANALGESICS:lST REPORT : ELECTRON MICROSCOPIC STUDIES ON THE ULTRASTRUCTURAL TRANSFORMATION OF MITOCHONDRIA IN THE CELLS OF ZONA FASCICULATA OF THE ADRENAL CORTEX IN MORPHINE ADDICTED RATS
- 6-Hydroxydopamine Lesion Prevents Induction of Tyrosine Hydroxylase by Haloperidol in the Rat Substantia Nigra, Pars Reticulata.
- Stimulus-Transcription Coupling can be studied by in situ Hybridization of Brain Slice Preparation. Selective c-fos Expression in Hippocampal CA3 Pyramidal Cells.
- Two forms of drebrins, developmentally regulated brain proteins, in rat.