STUDIES ON THE PHYSICAL DEPENDENCE POTENTIAL OF ANALGESICS
スポンサーリンク
概要
- 論文の詳細を見る
Influence of morphine on the fine structure of mitochondria in the cell of zona fasciculata of adrenal cortex in mice treated chronically with morphine pellets was studied using the electron microscope. The transformation of mitochondrial structure was observed 12 hours after morphine pellet implantation and the degree of transformation reached a maximum at 48 hours. These changes, however, disappeared within 4 days. On the 4th day after implantation, removal of the pellet or levallorphan challenge resulted in alteration of the mitochondria with evidence of withdrawal syndrome. Reinjection of morphine to the mice immediately after removal of the pellet, however, prevented the appearance of such mitochondrial transformation. Chlorpromazine or sodium pentobarbital did not affect on the transformation of mitochondria.
- 社団法人 日本薬理学会の論文
著者
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Yamamoto Hiroyuki
Department Of Cardiology Kurashiki Central Hospital
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Yano Ichiro
Department Of Pediatrics Daisan Hospital Jikei University School Of Medicine
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MURANO Tadashi
Department of Pharmacology, Wakayama Medical College
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SENDA Hiromi
Department of Pharmacology, Wakayama Medical College
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Yamamoto Hiroyuki
Department Of Applied Biology Faculty Of Textile Science And Technology Shinshu University
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MURANO Tadashi
Department of Pharmacology, Wakayama Aledical College
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YAMAMOTO Hiroyuki
Department of Pharmacology, Wakayama Medical College
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MURANO TADASHI
Department of Pharmacology, Osaka City University Medical School
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