STUDIES ON THE FUNCTION OF CELL MEMBRANE:7TH REPORT: INFLUENCE OF CCl<SUB>4</SUB> ADMINISTRATION ON SOLUBILIZATION OF THE ENZYMES IN ELECTRON TRANSPORT SYSTEM IN RAT LIVER PLASMA MEMBRANE AND MICROSOME
スポンサーリンク
概要
- 論文の詳細を見る
In liver microsomes of normal rats, both NADH-ferricyanide dehydrogenase and NADH-cytochrome c reductase were almost completely solubilized by addition of 0.5% DOC. Solubilization patterns were little affected by CCl<SUB>4</SUB> injection. In membranes, solubilization of dehydrogenase and reductase was less than that in microsomes. CCl<SUB>4</SUB> administration lowered the solubility of the dehydrogenase in membranes and increased three-fold the ratio of the reductase to the dehydrogenase remaining in the non-solubilized fraction. The reductase in membranes from CCl<SUB>4</SUB> treated rat liver was found to be more resistant to solubilization by DOC. The possibility of accumulation of NADH-cytochrome c reductase in plasma membranes after CCl<SUB>4</SUB> administration was discussed.
- 公益社団法人 日本薬理学会の論文
著者
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KUCHII Masato
Department of Pharmacology, Wakayama Medical College
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MURANO Tadashi
Department of Pharmacology, Wakayama Medical College
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Masuda Yasusuke
Department Of Toxicology Niigata College Of Pharmacy
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Yamamoto Hiroyuki
Department Of Applied Biology Faculty Of Textile Science And Technology Shinshu University
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MURANO Tadashi
Department of Pharmacology, Wakayama Aledical College
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MASUDA Yasusuke
Department of Pharmacology, Wakayama Aledical College
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YAMAMOTO Hiroyuki
Department of Pharmacology, Wakayama Medical College
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KUCHII Masato
Department of Pharmacology, Wakayama Aledical College
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MURANO TADASHI
Department of Pharmacology, Osaka City University Medical School
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