STUDIES ON THE FUNCTION OF CELL MEMBRANE : 6TH REPORT: INFLUENCE OF SEX HORMONES ON THE ELEVATION OF NADH-CYTOCHROME c REDUCTASE ACTIVITY IN LIVER PLASMA MEMBRANE OF CCl<SUB>4</SUB>-ADMINISTERED RATS
スポンサーリンク
概要
- 論文の詳細を見る
NADH-cytochrome c reductase and NADH dehydrogenase activities in liver cell membranes were not effected by orchiectomy and ovariectory. Time required for the elevation of these enzyme activities following CCl<SUB>4</SUB> administration in orchiectomized rats was, however, apparently shortened and comparable with that in the non-treated females. Administration of 17-α-methyltestosterone recovered completely the response to CCl<SUB>4</SUB> as was seen in the male controls. In female rats, ovariectomy or administration of diethylstilbestrol produced no effects on the CCl<SUB>4</SUB>induced changes of membrane enzyme activities. Membrane ATPase activity decreased following CCl<SUB>4</SUB> administration in such hormonal states of rats that the reductase and the dehydrogenase activities were increased. Male sex hormone appears to suppress changes of these enzyme activities in the membranes following CCl<SUB>4</SUB> administration.
著者
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KUCHII Masato
Department of Pharmacology, Wakayama Medical College
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Yamamoto Hiroyuki
Department Of Applied Biology Faculty Of Textile Science And Technology Shinshu University
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MURANO Tadashi
Department of Pharmacology, Wakayama Aledical College
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MASUDA Yasusuke
Department of Pharmacology, Wakayama Aledical College
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YAMAMOTO Hiroyuki
Department of Pharmacology, Wakayama Medical College
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KUCHII Masato
Department of Pharmacology, Wakayama Aledical College
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MURANO TADASHI
Department of Pharmacology, Osaka City University Medical School
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