STUDIES ON THE FUNCTION OF CELL MEMBRANE:2ND REPORT: ELEVATION OF NADH-CYTOCHROME c REDUCTASE ACTIVITY IN THE LIVER CELL MEMBRANE OF RATS FOLLOWING CCl<SUB>4</SUB> ADMINISTRATION
スポンサーリンク
概要
- 論文の詳細を見る
Distinct fractional zones of cell membranes in sucrose gradients were obtainable from homogenates of rat liver up to 6 hr (females) and 12 hr (males) following an i.p. injection of CCl<SUB>4</SUB> (0.2 ml/kg body wt.). CCl<SUB>4</SUB> administration to rats caused a marked elevation of NADH-cytochrome c reductase activity in the liver cell membrane. There was a remarkable difference between sexes with respect to time-course of the changes of the enzyme activity, viz., a. peak was reached 6 hr after administration in female rats and 12 hr in male rats with normal activity at 6 hr. Neither mitochondrial fractions nor microsomal fractions of rat liver displayed any significant alterations in NADH-cytochrome c reductase activity 6 hr after CCl<SUB>4</SUB> administration.
- 公益社団法人 日本薬理学会の論文
著者
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Yano Ichiro
Department Of Pediatrics Daisan Hospital Jikei University School Of Medicine
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KUCHII Masato
Department of Pharmacology, Wakayama Medical College
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Masuda Yasusuke
Department Of Toxicology Niigata College Of Pharmacy
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Yamamoto Hiroyuki
Department Of Applied Biology Faculty Of Textile Science And Technology Shinshu University
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MURANO Tadashi
Department of Pharmacology, Wakayama Aledical College
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MASUDA Yasusuke
Department of Pharmacology, Wakayama Aledical College
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YAMAMOTO Hiroyuki
Department of Pharmacology, Wakayama Medical College
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KUCHII Masato
Department of Pharmacology, Wakayama Aledical College
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MURANO TADASHI
Department of Pharmacology, Osaka City University Medical School
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Kuchii Masato
Department of Medicine, Wakayama Medical College
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