Effects of β-Adrenergic Agonists on Metabolic Activations of Human Neutrophils
スポンサーリンク
概要
- 論文の詳細を見る
Although effects of adrenergic agonists on metabolic activation of neutrophils have been studied for over a decade, amounts of released arachidonic acid and its metabolites from the cells activated by chemotactic peptide (FMLP) are so small that the results have been in conflict. In this study, we developed a method to obtain enough amount of arachidonic acid released to examine the action sites of adrenergic agonists with respects to the metabolic bursts of human neutrophils. First, superoxide generation from the cells was estimated and the results indicated that the adrenergic agonists, such as isoproterenol, salbutamol, procaterol and epinephrine, inhibited over 70% and 40% of the superoxide generation stimulated by FMLP and serum treated zymosan (STZ), respectively. Another metabolic activation, the release of arachidonic acid, was achieved by FMLP if the cells were incubated with merthiolate (20-80μM), but the merthiolate-treatment was ineffective on the cells activated by calcium ionophore (A23187). Isoproterenol and epinephrine decreased the arachidonic acid release only when the cells were activated by FMLP in the presence of merthiolate. In spite of the fact that isoproterenol (1 and 10 μM) hardly inhibited the arachidonic acid release activated by A23187,formations of leukotrienes were decreased up to approximately 70% of control level. Intracellular calcium concentration elevated by FMLP was hardly diminished by isoproterenol and salbutamol. From these observations, it appears likely that adrenergic agonists attenuate the signal transmission process of FMLP at a post-receptor site of action at a step before the activation of protein kinase C or phospholipase A_2.
- 公益社団法人日本薬学会の論文
著者
-
MASUDA Yasusuke
Department of Toxicology, Niigata College of Pharmacy
-
Masuda Y
Department Of Toxicology Niigata College Of Pharmacy
-
MASUDA YOSHINOBU
Department of Pharmacology, Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
-
Masuda Yasusuke
Department Of Toxicology Niigata College Of Pharmacy
-
Takanaka Koichiro
Department Of Toxicology Niigata College Of Pharmacy
-
Taniguchi K
Department Of Toxicology Niigata College Of Pharmacy
-
Taniguchi Katsuhiko
Department Of Toxicology Niigata College Of Pharmacy
-
MASUDA Yasusuke
Department of Pharmacology, Wakayama Aledical College
関連論文
- THE MODE OF ENHANCED ENTERAL ABSORPTION OF MACROMOLECULES BY LIPID-SURFACTANT MIXED MICELLES I
- EFFECT OF ADMINISTRATION ROUTE ON THE SELECTIVE LYMPHATIC DELIVERY OF CYCLOSPORIN A BY LIPID-SURFACTANT MIXED MICELLES
- ROLE OF THE DISPERSION SYSTEMS CONTAINING FUSOGENIC LIPIDS ON ENHANCED ABSORPTION OF POORLY ABSORBABLE DRUGS FROM THE GASTROINTESTINAL TRACT
- PROMOTION OF THE SELECTIVE LYMPHATIC DELIVERY OF CYCLOSPORIN A BY LIPID-SURFACTANT MIXED MICELLES
- Characteristics of Post-tetanic Contraction Induced by Naloxone in Guinea Pig Ileum
- DIFFERENTIAL ANTAGONISMS OF ANTICONVULSANTS TO VARIOUS COMPONENTS OF MAXIMAL SEIZURES INDUCED BY ELECTROSHOCK OR PENTYLENETETRAZOL IN MICE
- Assessment of Ocular Irritability of Liposome Preparations
- Efficacy of a Liposome Preparation of Anti-inflammatory Steroid as an Ocular Drug-Delivery System
- STUDIES ON THE FUNCTION OF CELL MEMBRANE : 6TH REPORT: INFLUENCE OF SEX HORMONES ON THE ELEVATION OF NADH-CYTOCHROME c REDUCTASE ACTIVITY IN LIVER PLASMA MEMBRANE OF CCl4-ADMINISTERED RATS
- COMPARATIVE STUDIES ON THE HEPATOTOXIC ACTIONS OF CHLOROFORM AND RELATED HALOGENOMETHANES IN NORMAL AND PHENOBARBITAL-PRETREATED ANIMALS
- STUDIES ON THE FUNCTION OF CELL MEMBRANE : 4TH REPORT: ELECTRON MICROSCOPIC OBSERVATIONS ON CHANGES IN ULTRA-STRUCTURE OF LIVER CELL MEMBRANES IN CCl4-TREATED RATS
- STUDIES ON THE PHYSICAL DEPENDENCE LIABILITY OF ANALGESICS : 4TH REPORT: ELECTRON MICROSCOPIC STUDY ON INTRAMITOCHONDRIAL STRUCTURE OF ZONA FASCICULATA CELLS IN ADRENAL CORTEX IN CODEINE ADDICTED RATS
- Effects of Monatepil Maleate, a New Ca^ Channel Antagonist With α_1 : Adrenoceptor Antagonistic Activity, on Cholesterol Absorption and Catabolism in High Cholesterol Diet : Fed Rabbits
- Protective Effect of Zonisamide, an Antiepileptic Drug, Against Transient Focal Cerebral Ischemia with Middle Cerebral Artery Occlusion-Reperfusion in Rats
- STUDIES ON THE FUNCTION OF CELL MEMBRANE : 8TH REPORT: BINDING OF CYTOCHROME c TO LIVER PLASMA MEMBRANE AND MICROSOME IN CCl4-POISONED RATS
- SUPPRESSION OF PHENACETIN-INDUCED METHEMOGLOBINEMIA BY DIETHYLDITHIOCARBAMATE AND CARBON DISULFIDE AND ITS RELATION TO PHENACETIN METABOLISM IN MICE
- CARBON TETRACHLORIDE-INDUCED LOSS OF MICROSOMAL GLUCOSE 6-PHOSPHATASE AND CYTOCHROME P-450 IN VITRO
- Effects of Tween 80 and Liposomes on the Corneal Permeability of Antiinflammatory Steroids
- Inhibitions of Metabolic Responses of Polymorphonuclear Leukocytes by Antiallergic Drugs
- Effects of β-Adrenergic Agonists on Metabolic Activations of Human Neutrophils
- Inhibitory Effects of Histamine H_1 Receptor Blocking Drugs on Metabolic Activations of Neutrophils
- STUDIES ON THE FUNCTION OF CELL MEMBRANE : 3RD REPORT: ON THE PURITY OF LIVER CELL MEMBRANE FRACTION ISOLATED FROM CCl4-TREATED RATS
- STUDIES ON THE PHYSICAL DEPENDENCE OF A NEW CENTRAL ANALGESIC; 1-(m-METHOXYPHENYL)-2-DIMETHYLAMINOMETHYL CYCLOHEXANOL (1) HCL (CG-315)
- STUDIES ON THE PHYSICAL DEPENDENCE LIABILITY OF ANALGESICS:3RD REPORT : ELECTRON MICROSCOPIC STUDY ON INTRAMITOCHONDRIAL STRUCTURE OF ZONA FASCICULATA CELLS IN ADRENAL CORTEX IN A NEW ANALGESIC, CG-315 CHRONICALLY ADMINISTERED RATS
- STUDIES ON PHARMACODYNAMIC ACTION OF N-ETHYLMALEIMIDE (NEM):3RD REPORT : NEM INDUCED HYPERGLYCEMIA IN RATS
- STUDIES ON THE FUNCTION OF CELL MEMBRANE:(1) LEAKAGE OF NADH-CYTOCHROME c REDUCTASE INTO PLASMA FROM LIVER CELLS IN CCl4-POISONED RATS
- STUDIES ON THE PHYSICAL DEPENDENCE LIABILITY OF ANALGESICS:2ND REPORT : RELATIONSHIP BETWEEN TRANSFORMATION OF INTRAMITOCHONDRIAL STRUCTURES IN ADRENOCORTICAL CELLS AND CORTICOSTERONE BIOSYNTHESIS IN MORPHINE ADDICTED RATS
- STUDIES ON THE FUNCTION OF CELL MEMBRANE:2ND REPORT: ELEVATION OF NADH-CYTOCHROME c REDUCTASE ACTIVITY IN THE LIVER CELL MEMBRANE OF RATS FOLLOWING CCl4 ADMINISTRATION
- STUDIES ON THE FUNCTION OF CELL MEMBRANE:5TH REPORT: CHARACTERIZATION OF NADH-CYTOCHROME c REDUCTASE OF LIVER CELL MEMBRANE IN NORMAL AND CCl4-TREATED RATS
- STUDIES ON THE FUNCTION OF CELL MEMBRANE:7TH REPORT: INFLUENCE OF CCl4 ADMINISTRATION ON SOLUBILIZATION OF THE ENZYMES IN ELECTRON TRANSPORT SYSTEM IN RAT LIVER PLASMA MEMBRANE AND MICROSOME
- STUDIES ON THE FUNCTION OF CELL MEMBRANE:9TH REPORT: PROTECTIVE ACTION OF SODIUM TAURINE N-CARBO-DITHIOATE (TDT) AGAINST CCl4-INDUCED BIOCHEMICAL CHANGES IN LIVER CELL MEMBRANE OF RATS
- A STUDY OF METABOLIC FATE OF A NEW CENTRAL ANALGETIC : 1-(M-METHOXY PHENYL)-2-DIMETHYL-AMINOMETHYLCYCLOHEXANOL (1) HCl (CG-315)
- Effects of various drugs on superoxide generation, arachidonic acid release and phospholipase A2 in polymorphonuclear leukocytes.
- Action sites of antiallergic drugs on human neutrophils.