A STUDY OF METABOLIC FATE OF A NEW CENTRAL ANALGETIC : 1-(M-METHOXY PHENYL)-2-DIMETHYL-AMINOMETHYLCYCLOHEXANOL (1) HCl (CG-315)
スポンサーリンク
概要
- 論文の詳細を見る
Subcutaneously or per orally administered CG-315 was rapidly absorbed and widely distributed in rat whole body, especially in the lungs, spleen, liver and kidneys etc. Most of the administered drug and its metabolites was excreted in the urine within 24 hr with a small amount in the feces. Part of absorbed CG-315 may be mainly metabolized in liver to O-, N- or both demethylated forms, some of which are conjugated with glucuronates. No difference was found in metabolism of CG-315 between non-tolerant and tolerant rats.
- 公益社団法人 日本薬理学会の論文
著者
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Masuda Yasusuke
Department Of Toxicology Niigata College Of Pharmacy
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Yamamoto Hiroyuki
Department Of Applied Biology Faculty Of Textile Science And Technology Shinshu University
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Furuta Hiroaki
Department Of Dental Pharmacology
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MURANO Tadashi
Department of Pharmacology, Wakayama Aledical College
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FURUTA Hiroaki
Department of Pharmacology, Wakayama Medical College
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HENMI Zenichi
Department of Pharmacology, Wakayama Medical College
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MASUDA Yasusuke
Department of Pharmacology, Wakayama Aledical College
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YAMAMOTO Hiroyuki
Department of Pharmacology, Wakayama Medical College
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MURANO TADASHI
Department of Pharmacology, Osaka City University Medical School
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