STUDIES ON THE FUNCTION OF CELL MEMBRANE:5TH REPORT: CHARACTERIZATION OF NADH-CYTOCHROME c REDUCTASE OF LIVER CELL MEMBRANE IN NORMAL AND CCl<SUB>4</SUB>-TREATED RATS
スポンサーリンク
概要
- 論文の詳細を見る
NADH-cytochrome c reductase activity of the cell membrane was not significantly inhibited by KCN, NaN<SUB>3</SUB>, Antimycin A or rotenone but was evidently inhibited by PCMB and also by NEM. Km values for NADH in NADH-cytochrome c reductase or NADH-ferricyanide dehydrogenase of the cell membrane were almost equal to those in the microsomes. These Km values were hardly affected by administration of CCl4<SUB>4</SUB>. Cytochrome b<SUB>5</SUB> and P-450 were identified in the cell membrane fraction, and the contents were normally remarkably low as compared with those in the microsomal fraction. However, they increased approx. two-fold following CCl<SUB>4</SUB> administration, while those in microsomes conversely diminished by half. NADH-cytochrorne b<SUB>5</SUB> reductase activity in the cell membrane fraction was approx. onethird as low as NADH-cytochrome c reductase activity. The former was virtually unaffected by administration of CCl<SUB>4</SUB>. It is proposed that NADH-cytochrome c reductase in the cell membrane originates from microsomes but not from mitochondria and that increase in the enzyme activity after CCl<SUB>4</SUB> administration may be caused by migration of hemo- and flavo- protein from endoplasmic reticulum to plasma membranes of liver cells in vivo.
- 公益社団法人 日本薬理学会の論文
著者
-
KUCHII Masato
Department of Pharmacology, Wakayama Medical College
-
Masuda Yasusuke
Department Of Toxicology Niigata College Of Pharmacy
-
Yamamoto Hiroyuki
Department Of Applied Biology Faculty Of Textile Science And Technology Shinshu University
-
MURANO Tadashi
Department of Pharmacology, Wakayama Aledical College
-
MASUDA Yasusuke
Department of Pharmacology, Wakayama Aledical College
-
YAMAMOTO Hiroyuki
Department of Pharmacology, Wakayama Medical College
-
KUCHII Masato
Department of Pharmacology, Wakayama Aledical College
-
MURANO TADASHI
Department of Pharmacology, Osaka City University Medical School
-
Kuchii Masato
Department of Medicine, Wakayama Medical College
関連論文
- Successful Treatment of Primary Cardiac Lymphoma With Atrioventricular Nodal Block
- PJ-762 The Ratio and Lesion Morphology of Recurrent Restenosis after Reimplantation with Sirolimus-eluting Stent for Restenosis after Sirolimus-eluting Stent Implantation(PJ128,Coronary Revascularization, PCI (DES) 5 (IHD),Poster Session (Japanese),The 73
- PJ-478 The Detection of Cancer with Multidetecter Computed Tomography Coronary Angiography(PJ081,CT/MRI (Coronary/Vascular) 3 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-408 Sirolimus-eluting Stent Implantation for In-stent Restenosis of Bare Metal Stent or Sirolimus-eluting Stent(PJ069,Coronary Revascularization, PCI (Restenosis/Others) 1 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japane
- PE-379 Late Restenosis of Sirolimus Eluting Stent Implantation in Chronic Total Occlusions(PE064,Coronary Revascularization, PCI (DES) 6 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-280 Unique Distribution of Stent Fracture and Stent Fracture with Restenosis after Sirolimus-Eluting Stent Implantation(PE047,Coronary Revascularization, PCI (DES) 4 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circ
- PE-134 Is Previous Angiography as Follow up Useful to Predict Very Late Stent Thrombosis?(PE023,Coronary Revascularization, PCI (DES) 3 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OJ-255 Usefulness of Stress Myocardial Perfusion Imaging (MPI) in Detecting Significant Coronary Artery Stenosis in Multidetector Row Computed Tomography (MDCT) Era(OJ43,Nuclear Cardiology (Coronary, Myocardium) (I),Oral Presentation (Japanese),The 73rd A
- OJ-121 Predictors of Recurrent Restenosis after Treatment of Bifurcation Lesions with the Two-stent Strategy(OJ21,Coronary Revascularization, PCI (Complex Lesions) 2 (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Cir
- OE-403 Stent Fracture and Stent Thrombosis after Sirolimus-eluting Stent Implantation(OE68,Coronary Revascularization, PCI (Restenosis/Others) 4 (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-188 Prevalence and Predictors of Early and Late Restenosis after Sirolimus-Eluting Stent Implantation for de novo Lesion(OE32,Coronary Revascularization, PCI (Restenosis/Others) 2 (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of
- PJ-657 Optimal Strategy of Restenosis with Stent Fracture after Sirolimus-eluting stent Implantation(Coronary revascularization, PCI(24)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-258 The 2-year Follow-up Results of Drug Eluting Stent Implantation for the de novo Unprotected Left Main Coronary Artery Disease.(Coronary revascularization, PCI(19)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circ
- PE-049 The Long-Term Predictors of Restenosis and Target-Lesion-Revascularization after Drug-Eluting-Stent Implantation for the de novo Unprotected Left Main Coronary Artery Disease.(Coronary revascularization, PCI(07)(IHD),Poster Session(English),The 72n
- OE-004 Late Restenosis After Sirolimus-eluting Stent Implantation : The Impact of Lesion Complexity(Coronary revascularization, PCI(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-025 Middle-term angiographic follow-up of BioMatrix^ stent implantation for left main to left anterior descending artery(Forefront Updates in PCI(01)(IHD),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Soc
- PJ-744 Long-term Outcome of Treatment of De Novo Right Coronary Artery Ostial Lesions, Comparison with Drug-eluting Stents and Bare Metal Stents(Coronary revascularization, PCI-20, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-601 Prevalence of Side Effects of Clopidgrel Which was Prescribed to the Patients who Discontinued Ticlopidine due to its Side Effects(Coronary revascularization, PCI-16, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-266 The Angiographical Findings of the Late Restenosis : Comparison Between SES AND BMS Lesions(Restenosis basic/clinical-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-485 Clinical Outcomes in Chronic Hemodialysis Patients : Initial and One-Year Follow-Up Results of the j-CYPHER Registry(Coronary revascularization, PCI-10, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-080 Middle Term Clinical and Angiographic Outcomes of BioMatrix^ Stent Implantation for Left Main Coronary Artery Stenosis(Coronary revascularization, PCI-05, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-243 Predictors of Angiographic Stent Fracture and Stent Fracture with Restenosis after Sirolimus-eluting stent (SES) Implantation(Coronary revascularization, PCI-03, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Left Ventricular Reconstruction with or without Mitral Annuloplasty
- Impact of Subvalvular Procedure for Ischemic Mitral Regurgitation on Leaflet Configuration, Mobility, and Recurrence
- 5 Subvalvular Procedure for Ischemic Mitral Regurgitation improved Anterior Leaflet Configuration and Motion with Reduction of Recurrence(Symposium 9 (SY-09) (M) New Insight for Treatment of Ischemic Mitral Regurgitation,Special Program,The 72nd Annual Sc
- Pharmacological Differences between Liu-Jun-Zi-Tang, a Traditional Chinese Herbal Medicine, and Domperidone on Isolated Guinea-Pig Ileum(Pharmacology)
- Involvement of Peripheral Mechanism in the Verapamil-Induced Potentiation of Morphine Analgesia in Mice
- Naloxone-Precipitated Morphine Withdrawal Elicits Increases in c-fos mRNA Expression in Restricted Regions of the Infant Rat Brain
- Characteristics of Post-tetanic Contraction Induced by Naloxone in Guinea Pig Ileum
- OE-038 Initial Experience and Efficacy of the Retrograde Approach Technique for Chronic Total Occlusions(Coronary revascularization, PCI-01, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-115 Reccurent Restenosis after Treatment of Sirolimus Eluting Stent Restenosis(Coronary Revascularization (clinical) 2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 3 Prevalence and Clinical Implications of Stent Fracture After Sirolimus-Eluting Stent Implantation : The Impact of Lesion Complexity(Drug-eluting stent, current issues and perspective, The 71st Annual Scientific Meeting of the Japanese Circulation Societ
- PJ-672 Long Term Outcomes after Percutaneous Coronary Intervention(PCI) in Patient with Chronic Total Occlusion(CTO)(Coronary revascularization, PCI-22 (IHD) PJ113,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Ci
- PJ-524 Initial Experience of the New Tapered-tip Guide-wire in the Treatment of Chronic Total Occlusions(Coronary revascularization, PCI-19 (IHD) PJ88,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Soc
- PJ-516 Long-term Results of Sirolimus-eluting Stent in Coronary Lesions of Hemodialyzed Patients(Coronary revascularization, PCI-18 (IHD) PJ87,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-421 Predictors of Recurrent Restenosis after Sirolimus-eluting Stent Implantation for In-stent Restenosis Lesions(Restenosis, basic/clinical-5 (IHD) PJ71,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulati
- PE-218 Long-term Follow-up of Parmacological and Ablation Therapy in Patients with Paroxysmal Atrial Fibrillation Who Develop Atrial Flutter(Arrhythmia, diagnosis/pathophysiology/EPS-9 (A) PE37,Poster Session (English),The 70th Anniversary Annual Scientif
- OJ-231 Prevalence and Clinical Impact of Angiographic Stent Fracture and Stent Hinge Movement after Sirolimus-eluting stent (SES) Implantation in Complex PCI(Restenosis, basic/clinical-2 (IHD) OJ39,Oral Presentation (Japanese),The 70th Anniversary Annual
- Two Types of Transient Left Ventricular Wall Motion Abnormality Mimicking Acute Coronary Syndrome(Acute Coronary Syndrome, Basic/Clinical 5 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- The Effecacy of the Cypher Stenting for In-stent Restenosis (ISR)(Coronary Revascularization, PTCA/Stent/DCA/Rotablator/New Device 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Triple Marker Screening for Trisomy 21, Trisomy 18 and Open Neural Tube Defects in Singleton Pregnancies of Native Japanese Pregnant Women
- Dimeric Inhibin A as a Fourth Marker for Down's Syndrome Maternal Serum Screening in Native Japanese Women
- Surgical Treatment of Coronary Artery Aneurysm with Coronary Artery Fistula
- Detection of Chlamydia pneumoniae in blood of stroke patients
- Role of Pharmacokinetic Effects in the Potentiation of Morphine Analgesia by L-Type Calcium Channel Blockers in Mice
- Repeated inhalation of adrenomedullin inhibits monocrotaline-induced pulmonary hypertension in rats
- Elevated circulating level of ghrelin in cachexia associated with chronic heart failure
- Antimicrobial activity of everninomicin against clinical isolates of Enterococcus spp., Staphylococcus spp., and Streptococcus spp. tested by Etest
- Comparison of in-vitro activities of SCH27899 and other antibiotics against Mycoplasma pneumoniae
- Characterization of MRSA transmission in an emergency medical center by sequence analysis of the 3'-end region of the coagulase gene
- Relatedness between the Coagulase Gene 3'-End Region and Coagulase Serotypes among Staphylococcus aureus Strains
- Evaluation of in-vitro activity of new quinolones, macrolides, and minocycline against Mycoplasma pneumoniae
- Kinetic Equation for Template-Dependent Polymerase Reactions and Its Application to Thermus thermophilus DNA Polymerase
- Mycoplasma pneumoniae DNA Could Not Be Detected in Blood Samples Obtained from Japanese Stroke Patients
- PJ-474 Impact of Bifurcation Lesions on PCI for CTO(Coronary Revascularization, PTCA/Stent/DCA/Rotablator/New Device 12 (IHD) : PJ79)(Poster Session (Japanese))
- Palliative Stent-Graft Insertion Followed by an Allograft Replacement for an Infected and Ruptured Aortic Aneurysm
- Effects of Peptidase Inhibitors, jp-Ala2, Met5]-Enkephalinamide and Antiserum to Methionine-Enkephalin Microinjected Into the Caudal Periaqueductal Gray on Morphine Withdrawal in Rats
- Possible Involvement of the Total Amount of Morphine Infused in the Development of Acute Morphine Dependences in Rats
- No Relation of Plasma Morphine Level to the Severity of Naloxone-Induced Withdrawal in Acute Morphine-Dependent Rats
- Effects of Phosphine-Plasma Treatment on Characteristics of Au/n-InP Schottky Junctions
- Hydrogenation of InP by Phosphine Plasma
- Antenatal Diagnosis of Prune Belly Syndrome at 11 Weeks of Gestation
- Emergency Postpartum Hysterectomy in Obstetric Practice
- A Neuro-Based Optimization Algorithm for Three Dimensional Cylindric Puzzles (Special Section of Papers Selected from ITC-CSCC'96)
- Choroidal Neovascular Membrane Adjacent to an Old Macular Hole Sparing the Center of the Hole
- Photodynamic Therapy for Typical Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy : A 30-Month Multicenter Study in Hyogo, Japan
- Enlargement of the Globe With Ocular Malformations in c-Myc Transgenic Mice
- Genetic Identification of Members of the Genus Corynebacterium at Genus and Species Levels with 16S rDNA-Targeted Probes
- Evaluation of the activity of antimicrobial agents against Legionella pneumophila multiplying in a human monocytic cell line, THP-1, and an alveolar epithelial cell line, A549
- Comparative uptake of grepafloxacin and ciprofloxacin by a human monocytic cell line, THP-1
- PJ-410 Radiocontrast-induced nephropathy following elective PCI(Kidney/Renal Circulation 2 (H) : PJ69)(Poster Session (Japanese))
- PJ-108 Efficacy of Conquest Guidewire and New technique for In-Stent Reocclusion.(Coronary Revascularization, PTCA/Stent/DCA/Rotablator/New Device 5 (IHD) : PJ18)(Poster Session (Japanese))
- PJ-106 The Predictors of reocclusion after percutaneous coronary intervention (PCI) for chronic total occlusion lesions (CTOs)(Coronary Revascularization, PTCA/Stent/DCA/Rotablator/New Device 5 (IHD) : PJ18)(Poster Session (Japanese))
- OJ-433 Clinical experience with balloon pulmonary angioplasty for chronic pulmonary thromboembolism(Pulmonary Circulation 1 (H) : OJ53)(Oral Presentation (Japanese))
- OJ-114 Clinical Effects of the filter type distal protection device, Angioguard on the initial results of elective Percutaneous Coronary Intervention (PCI)(Coronary Revascularization, PICA/Stent/DCA/Rotablator/New Device 2 (IHD) : OJ14)(Oral Presentation
- OJ-073 Determinants of procedural failure in chronic total occlusion (CTO)(Coronary Revascularization, PICA/Stent/DCA/Rotablator/New Device 1 (IHD) : OJ9)(Oral Presentation (Japanese))
- OJ-072 Frequency of the edge effect after stent implantation in Percutaneous Coronary Intervention (PCI)(Coronary Revascularization, PICA/Stent/DCA/Rotablator/New Device 1 (IHD) : OJ9)(Oral Presentation (Japanese))
- OJ-071 Initial experience of Angioguard(Coronary Revascularization, PICA/Stent/DCA/Rotablator/New Device 1 (IHD) : OJ9)(Oral Presentation (Japanese))
- Efficacy of Superselective Drug Infusion into Diseased Coronary Artery Using Infusion Catheter (SDI) to No/Slow Flow during Rotational Atherectomy (PTCRA)
- STUDIES ON THE FUNCTION OF CELL MEMBRANE : 6TH REPORT: INFLUENCE OF SEX HORMONES ON THE ELEVATION OF NADH-CYTOCHROME c REDUCTASE ACTIVITY IN LIVER PLASMA MEMBRANE OF CCl4-ADMINISTERED RATS
- COMPARATIVE STUDIES ON THE HEPATOTOXIC ACTIONS OF CHLOROFORM AND RELATED HALOGENOMETHANES IN NORMAL AND PHENOBARBITAL-PRETREATED ANIMALS
- STUDIES ON THE FUNCTION OF CELL MEMBRANE : 4TH REPORT: ELECTRON MICROSCOPIC OBSERVATIONS ON CHANGES IN ULTRA-STRUCTURE OF LIVER CELL MEMBRANES IN CCl4-TREATED RATS
- STUDIES ON THE PHYSICAL DEPENDENCE LIABILITY OF ANALGESICS : 4TH REPORT: ELECTRON MICROSCOPIC STUDY ON INTRAMITOCHONDRIAL STRUCTURE OF ZONA FASCICULATA CELLS IN ADRENAL CORTEX IN CODEINE ADDICTED RATS
- STUDIES ON THE FUNCTION OF CELL MEMBRANE : 8TH REPORT: BINDING OF CYTOCHROME c TO LIVER PLASMA MEMBRANE AND MICROSOME IN CCl4-POISONED RATS
- THE EFFECT OF COCAINE ON THE 3H-NOREPINEPHRINE UPTAKE BY COLD STORED AORTA FROM RABBIT
- SUPPRESSION OF PHENACETIN-INDUCED METHEMOGLOBINEMIA BY DIETHYLDITHIOCARBAMATE AND CARBON DISULFIDE AND ITS RELATION TO PHENACETIN METABOLISM IN MICE
- CARBON TETRACHLORIDE-INDUCED LOSS OF MICROSOMAL GLUCOSE 6-PHOSPHATASE AND CYTOCHROME P-450 IN VITRO
- Effects of β-Adrenergic Agonists on Metabolic Activations of Human Neutrophils
- Inhibitory Effects of Histamine H_1 Receptor Blocking Drugs on Metabolic Activations of Neutrophils
- STUDIES ON THE FUNCTION OF CELL MEMBRANE : 3RD REPORT: ON THE PURITY OF LIVER CELL MEMBRANE FRACTION ISOLATED FROM CCl4-TREATED RATS
- STUDIES ON THE PHYSICAL DEPENDENCE OF A NEW CENTRAL ANALGESIC; 1-(m-METHOXYPHENYL)-2-DIMETHYLAMINOMETHYL CYCLOHEXANOL (1) HCL (CG-315)
- STUDIES ON THE PHYSICAL DEPENDENCE LIABILITY OF ANALGESICS:3RD REPORT : ELECTRON MICROSCOPIC STUDY ON INTRAMITOCHONDRIAL STRUCTURE OF ZONA FASCICULATA CELLS IN ADRENAL CORTEX IN A NEW ANALGESIC, CG-315 CHRONICALLY ADMINISTERED RATS
- STUDIES ON PHARMACODYNAMIC ACTION OF N-ETHYLMALEIMIDE (NEM):3RD REPORT : NEM INDUCED HYPERGLYCEMIA IN RATS
- STUDIES ON THE FUNCTION OF CELL MEMBRANE:(1) LEAKAGE OF NADH-CYTOCHROME c REDUCTASE INTO PLASMA FROM LIVER CELLS IN CCl4-POISONED RATS
- STUDIES ON THE PHYSICAL DEPENDENCE LIABILITY OF ANALGESICS:2ND REPORT : RELATIONSHIP BETWEEN TRANSFORMATION OF INTRAMITOCHONDRIAL STRUCTURES IN ADRENOCORTICAL CELLS AND CORTICOSTERONE BIOSYNTHESIS IN MORPHINE ADDICTED RATS
- STUDIES ON THE FUNCTION OF CELL MEMBRANE:2ND REPORT: ELEVATION OF NADH-CYTOCHROME c REDUCTASE ACTIVITY IN THE LIVER CELL MEMBRANE OF RATS FOLLOWING CCl4 ADMINISTRATION
- STUDIES ON THE FUNCTION OF CELL MEMBRANE:5TH REPORT: CHARACTERIZATION OF NADH-CYTOCHROME c REDUCTASE OF LIVER CELL MEMBRANE IN NORMAL AND CCl4-TREATED RATS
- STUDIES ON THE FUNCTION OF CELL MEMBRANE:7TH REPORT: INFLUENCE OF CCl4 ADMINISTRATION ON SOLUBILIZATION OF THE ENZYMES IN ELECTRON TRANSPORT SYSTEM IN RAT LIVER PLASMA MEMBRANE AND MICROSOME
- STUDIES ON THE FUNCTION OF CELL MEMBRANE:9TH REPORT: PROTECTIVE ACTION OF SODIUM TAURINE N-CARBO-DITHIOATE (TDT) AGAINST CCl4-INDUCED BIOCHEMICAL CHANGES IN LIVER CELL MEMBRANE OF RATS
- A STUDY OF METABOLIC FATE OF A NEW CENTRAL ANALGETIC : 1-(M-METHOXY PHENYL)-2-DIMETHYL-AMINOMETHYLCYCLOHEXANOL (1) HCl (CG-315)