STUDIES ON THE PHYSICAL DEPENDENCE LIABILITY OF ANALGESICS:2ND REPORT : RELATIONSHIP BETWEEN TRANSFORMATION OF INTRAMITOCHONDRIAL STRUCTURES IN ADRENOCORTICAL CELLS AND CORTICOSTERONE BIOSYNTHESIS IN MORPHINE ADDICTED RATS
スポンサーリンク
概要
- 論文の詳細を見る
Influence of morphine on the transformation of intramitochondrial structure in rat adrenocortical cells and the response of isolated adrenals to ACTH in corticosterone biosynthesis was comparatively studied. Administering morphine 20 mg/kg to rats, the decrease in the sensitivity of cortical cells to ACTH in steroidogenesis was observed to be parallel in time to the onset of transformation of mitochondria, while withdrawal of morphine in addicted rats resulted in a similar change. Re-administration of morphine to the withdrawn rats caused nearly complete recovery to the original state within a few hr of both mitochondrial structure and sensitivity to ACTH.
- 公益社団法人 日本薬理学会の論文
著者
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Yano Ichiro
Department Of Pediatrics Daisan Hospital Jikei University School Of Medicine
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Masuda Yasusuke
Department Of Toxicology Niigata College Of Pharmacy
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Yamamoto Hiroyuki
Department Of Applied Biology Faculty Of Textile Science And Technology Shinshu University
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MURANO Tadashi
Department of Pharmacology, Wakayama Aledical College
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MIKITA Shinji
Department of Pharmacology, Wakayama Medical College
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MASUDA Yasusuke
Department of Pharmacology, Wakayama Aledical College
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YAMAMOTO Hiroyuki
Department of Pharmacology, Wakayama Medical College
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MURANO TADASHI
Department of Pharmacology, Osaka City University Medical School
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