STUDIES ON PHARMACODYNAMIC ACTION OF N-ETHYLMALEIMIDE (NEM):2ND REPORT : AN INFLAMMATORY PROPERTY OF NEM IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
NEM administered i.p. produced apparent accumulation- of exudative ascites, followed by an increase in hematocrit values and neutrophilia in differential leukocytes counts. Dilatation of vascular capillaries together with hyperemia, scattered foci of perivascular infiltration of monocytes and precipitation of fibrin in mesentery were histologically observed after administration of NEM. These phenomena were not observed in the liver. NEM, when intracutaneously administered, resulted in obvious edema in rat hind paw with a marked increase in capillary permeability. The inflammatory action of NEM was completely blocked by cysteine, but not by cortisone or indomethadine, suggesting that NEM induced edema results from the reaction with selective SH groups in tissues.
- 公益社団法人 日本薬理学会の論文
著者
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Yano Ichiro
Department Of Pediatrics Daisan Hospital Jikei University School Of Medicine
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OKADA Nobuyuki
Department of Pharmacology, Wakayama Medical College
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Yamamoto Hiroyuki
Department Of Applied Biology Faculty Of Textile Science And Technology Shinshu University
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MURANO Tadashi
Department of Pharmacology, Wakayama Aledical College
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YAMAMOTO Hiroyuki
Department of Pharmacology, Wakayama Medical College
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OKADA Nobuyuki
Department of Pharmacology, Wakayama Aledical College
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MURANO TADASHI
Department of Pharmacology, Osaka City University Medical School
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