Serial Clinical and Angiographic Follow-Up After Phosphorylcholine-Coated Stent Implantation
スポンサーリンク
概要
- 論文の詳細を見る
The efficacy of drug-eluting stents (DES) has been proven, but concerns about late complications after DES have been raised. Polymers that do not increase inflammatory or hypersensitivity reactions which may contribute to late complications are needed for new generation DES. To evaluate the safety and efficacy of phosphorylcholine-polymer coating, we investigated serial clinical and angiographic outcomes after phosphorylcholine-coated stent placement. Seventy-five consecutive patients treated with a BiodivYsio phosphorylcholine-coated stent for de novo lesions at our institute between October 2001 and August 2002 were enrolled. Six-month follow-up angiography was performed in 71 lesions (94.7%), and angiographic restenosis was found in 19 lesions (26.8%). Target lesion revascularization (TLR) was performed in 10 lesions (14.1%). Eighteen-month follow-up angiography was performed in 58 (95.1%) of the remaining 61 lesions (excluding TLR lesions), and angiographic restenosis was found in only 3 lesions. The cumulative MACE-free survival rate was 86.3%, 83.6%, and 78.6% at 6-month, 18-month, and 8-year follow-up, respectively. There were no episodes of stent thrombosis. Late loss decreased significantly from 0.74 ± 0.40 mm (6-months) to 0.51 ± 0.46 mm (18-months) (P < 0.0001). Phosphorylcholine-coated stent implantation was associated with acceptable clinical and angiographic results. Phosphorylcholine-coating may be an ideal polymer for new generation DESs.
著者
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Hosogi Shingo
Department of Cardiology, Kurashiki Central Hospital
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Maruo Takeshi
Department of Cardiology, Kurashiki Central Hospital
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Habara Seiji
Department of Cardiology, Kurashiki Central Hospital
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Tasaka Hiroshi
Department of Cardiology, Kurashiki Central Hospital
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Otsuru Suguru
Department of Cardiology, Kurashiki Central Hospital
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Katoh Harumi
Department of Cardiology, Kurashiki Central Hospital
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Okamoto Yoji
Department Of Cardiology Kurashiki Central Hospital
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Mitsudo Kazuaki
Department Of Cardiology
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Hirono Akitoshi
Department Of Cardiology Kurashiki Central Hospital
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Maruo Takeshi
Department Of Cardiology Kurashiki Central Hospital
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Saito Naoki
Department Of Cardiology Kurashiki Central Hospital
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Hosogi Shingo
Department Of Cardiology Kurashiki Central Hospital
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Fuku Yasushi
Department Of Cardiology Kurashiki Central Hospital
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Habara Seiji
Department Of Cardiology Hiroshima City Asa Hospital
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Hasegawa Daiji
Department Of Cardiology Hiroshima City Asa Hospital
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Fujii Satoki
Department Of Cardiology Kurashiki Central Hospital
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Kusunose Mana
Department Of Cardiology Kochi Health Sciences Center
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Kadota Kazushige
Department Of Cardiology Kurashiki Central Hospital
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Oka Naoki
Department Of Cardiology Kurashiki Central Hospital
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Tasaka Hiroshi
Department Of Cardiology Kurashiki Central Hospital
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Goto Tsuyoshi
Department Of Applied Biochemistry Faculty Of Applied Biological Science Hiroshima University
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Tsujimoto Yuki
Department Of Cardiology Kurashiki Central Hospital
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Yamamoto Hiroyuki
Department Of Applied Biology Faculty Of Textile Science And Technology Shinshu University
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Tanaka Hiroyuki
Department Of Anesthesia And Clinical Research Institute National Hospital Organization Kyushu Medic
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Shigemoto Yoshikazu
Department of Cardiology, Kurashiki Central Hospital
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