Interferon-γ Elevates Nicotinamide N-Methyltransferase Activity and Nicotinamide Level in Human Glioma Cells
スポンサーリンク
概要
- 論文の詳細を見る
Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotinamide. NNMT is strongly expressed in tumor cells and an increase in NNMT activity may reduce cellular nicotinamide level and thereby promote cell survival in the cells. However, there has been no report of a relationship between NNMT activity and nicotinamide level in tumor cells. We report herein that human glioma cells produce relatively large amounts of NNMT and that when these cells are cultured in the presence of interferon-γ (IFN-γ) their 1-methylnicotinamide levels increase. To clarify the mechanisms by which IFN-γ increases 1-methylnicotinamide levels in these cells, we measured NNMT activity and the levels of NNMT expression, nicotinamide and nicotinamide adenine dinucleotide (NAD+) in the presence and absence of IFN-γ. We also examined whether addition of exogenous 1-methylnicotinamide directly affects cell viability and/or the cellular levels of 1-methylnicotinamide, nicotinamide and NAD+. While addition of 1-methylnicotinamide increased the total amount of cellular 1-methylnicotinamide present, it did not affect nicotinamide or NAD+ levels, or cell viability. Conversely, IFN-γ significantly increased NNMT activity and the nicotinamide cellular concentration, while leaving NNMT expression and the NAD+ cellular concentration unchanged. Therefore, the increase in the 1-methylnicotinamide level found when IFN-γ is present in culture may be a consequence of increases in both the nicotinamide concentration and NNMT activity, whereas, 1-methylnicotinamide did not influence nicotinamide levels, NAD+ levels, or cell viability per se. These results suggest that an increase in NNMT activity does not always reduce cellular nicotinamide concentration in tumor cells.
- 2010-04-01
著者
-
YAMADA Kazuo
Department of Biochemistry, Faculty of Medicine, Shimane University
-
MIYAZAKI Takeshi
Department of Neurosurgery, Faculty of Medicine, Shimane University
-
HARA Nobumasa
Department of Biochemistry, Faculty of Medicine, Shimane University
-
TSUCHIYA Mikako
Department of Biochemistry, Faculty of Medicine, Shimane University
-
Hara N
Department Of Biochemistry Faculty Of Medicine Shimane University
-
Hara Nobumasa
Department Of Biochemistry Faculty Of Medicine Shimane University
-
Tsuchiya Mikako
Department Of Biochemistry Faculty Of Medicine Shimane University
-
Yamada Kazuo
Laboratory For Molecular Psychiatry Riken Brain Science Institute
-
Tsuchiya M.
Department Of Biochemistry Faculty Of Medicine Shimane University
-
Terashima Masaharu
Department Of Biochemistry Shimane Medical University
-
Miyazaki Takeshi
Department Of Neurosurgery Faculty Of Medicine Shimane University
-
Miyaoka Tsuyoshi
Department Of Biochemistry Shimane Medical University
-
Terashima Masaharu
Department Of Biochemistry Faculty Of Medicine Shimane University
-
Yamada Kazuo
Department Of Biochemistry Faculty Of Medicine Shimane University
-
Yamada Kazuo
Department Of Architecture Faculty Of Engineering Aichi Institute Of Technoligy
-
Miyazaki Takeshi
Department Of Materials Science And Technology Nagaoka University Of Technology
-
Miyazaki Takeshi
Department of Applied Chemistry, Faculty of Engineering, Osaka University
-
Yamada Kazuo
Department of Applied Molecular Chemistry, College of Industrial Technology, Nihon University
関連論文
- Association of Cerebral Venous Malformation with Glioblastoma : Case Report
- Interferon-γ Elevates Nicotinamide N-Methyltransferase Activity and Nicotinamide Level in Human Glioma Cells
- EFFECTS OF [K^+]_0 ON ANISOTROPIC CONDUCTION PROPERTIES OF CANINE VENTRICULAR MUSCLES : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Electrophysiology (I)
- -30add.-NEW BODY SURFACE ISOPOTENTIAL MAPPING SYSTEM USING A MICROPROCESSOR : Electrocardiography : PROCEEDINGS OF THE 42nd ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- DIVERSE CHARACTERISTICS IN POTENTIAL WAVEFORM OF HIS-PURKINJE SYSTEM : Experimental and Simulation Studies
- EFFECTS OF KW-3049, A NEWLY DEVELOPED CALCIUM ANTAGONIST, ON RABBIT SINUS NODES AND GUINEA PIG VENTRICULAR MUSCLES
- Endocardial Excitation and Conduction During Reperfusion Arrhythmias : SYMPOSIUM ON VENTRICULAR ARRHYTHMIA : BASIC AND CLINICAL STUDIES : 50th Annual Scientific Session of the Japanese Circulation Society
- REFLEX CHANGES IN ATRIOVENTRICULAR CONDUCTIVITY DUE TO THE AFFERENT STIMULATION OF THE CAT CAUDOVAGAL NERVE : Arrhythmia : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- THE MECHANISM OF OVERDRIVE SUPPRESSION. : ACTIVATION OF ELECTROGENIC SODIUM PUMP FOLLOWRNG RAPID STIMULATION : IIIrd Auditorium
- IN VITRO STUDY ON THE CAUSE OF INTRAVENTRICULAR ABERRANT CONDUCTION. : COMPARISON OF THE FUNCTIONAL REFRACTORY PERIOD BETWEEN THE CANINE RIGHT AND LEFT BUNDLE BRANCH SYSTEMS : IVth Auditorium : PROCEEDINGS OF THE 40TH ANNUAL MEETING OF THE JAPANESE CIRCUL
- Feasibility of Using a Human Nucleus Pulposus Cell Line as a Cell Source in Cell Transplantation Therapy for Intervertebral Disc Degeneration
- Immortalization of Human Nucleus Pulposus Cells by a Recombinant SV40 Adenovirus Vector : Establishment of a Novel Cell Line for the Study of Human Nucleus Pulposus Cells
- THE BODY SURFACE ISOPOTENTIAL MAPS OF THE NON-TRANSMURAL INFARCTIONS : A Simulation Study of Excitation Spread in a Ventricular Model
- MONOCLONAL ANTIBODIES AGAINST KERATINS BIND TO INTERCALATED DUCT AND DUCTAL BASAL CELLS OF NORMAL SALIVARY GLANDS IN PARAFFIN SECTIONS
- Analysis of a Nationwide Survey on Treatment and Outcomes of Congenital Hydrocephalus in Japan
- Nationwide Survey of the Etiology and Associated Conditions of Prenatally and Postnatally Diagnosed Congenital Hydrocephalus in Japan
- THE CONTIBUTION OF THE PURKINJE SYSTEM TO THE ENDOCARDIAL EXCITATION SPREAD IN THE RIGHT VENTRICLE : Arrhythmia II : IInd Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Tokyo, 1979
- -67-EFFECTS OF HYPOXIA OR LOW pH ON THE ALTERNATION OF CANINE VENTRICULAR ACTION POTENTIALS OCCURRING AFTER A SUDDEN INCREASE IN DRIVING RATE : Ischemic Heart Disease : PROCEEDINGS OF THE 42nd ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Treatment of Severe Localized Cerebral Vasospasm Following Recurrent Hemorrhage from Middle Cerebral Artery Aneurysm : Case Report
- Increased Risk of Cerebral Thrombo-embolic Complication during Gradual Carotid Artery Occlusion Combined with Extra-and Intracranial Bypass Surgery in the Treatment of an Inaccessible Carotid Aneurysm
- Evaluation of Masked Neurological Disorders in the Chronic Stage after Middle Cerebral Artery Occlusion in Rats : Methamphetamine-induced Rotation and Regional Glucose Metabolism in Basal Ganglia
- Dolichoectatic Basilar Artery Treated by Reducing Hemodynamic Stress : Report of Two Cases
- A STUDY ON INTRAATRIAL CONDUCTION : THE RELATIONSHIP BETWEEN PACEMAKER LOCATION AND P WAVE CONFIGURATION
- DIAGNOSIS OF ANTERIOR MYOCARDIAL INFARCTION BY BODY SURFACE ISOPOTENTIAL MAPPING. : CORRELATION TO LEFT VENTRICULOGRAMS : Electrocardiography・Vectorcardiography II : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- FOLLOW UP STUDY WITH BODY SURFACE ISOPOTENTIAL MAPS ON PATIENTS WITH SURGICALLY INDUCED RIGHT BUNDLE BRANCH BLOCK : Electrocardiography・Vectorcardiography II : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- THE MECHANISMS OF VENTRICULAR TACHYCARDIA DURING CORONARY ARTERY OCCLUSION IN DOGS : Arrhythmia・Electrophysiology : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- DIAGNOSIS OF INFEROPOSTERIOR MYOCARDIAL INFARCTION BY BODY SURFACE ISOPOTENTIAL MAPPING : CORRELATION BETWEEN DEPARTURE MAPS AND LEFT VENTRICULOGRAMS : The Fifth Conference on Vectorcardiography
- BODY SURFACE ISOPOTENTIAL MAPS OF THE TRANSIENT BLOCK OF THE MAIN RIGHT BUNDLE : Electrocardiography : IInd Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Tokyo, 1979
- BODY SURFACE ISOPOTENTIAL MAPS IN DOGS WITH EXPERIMENTAL MYOCARDIAL INFARCTION : Electrocardiography : IInd Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Tokyo, 1979
- DETERMINATION OF THE OPTIMAL NUMBER AND POSITIONS OF LEADPOINTS FOR BODY SURFACE ISO-POTENTIAL MAPPING : A PRELIMINARY REPORT : THE IV CONFERENCE ON VECTORCARDIOGRAPHY
- VCG AND BODY SURFACE ISOPOTENTIAL MAPS OF CANINE HEARTS IN EXPERIMENTALLY INDUCED INCOMPLETE RIGHT BUNDLE BRANCH BLOCK : THE III CONFERENCE ON VECTORCARDIOGRAPHY
- EXPERIMENTAL STUDY ON THE BODY SURFACE ISOPOTENTIAL MAPS OF THE INCOMPLETE RIGHT BUNDLE BRANCH BLOCK. : RELATIONSHIP BETWEEN THE EPICARDIAL ACTIVATION PROCESS AND THE BODY SURFACE ISOPOTENTIAL MAPS BY INCISING THE RIGHT LATERAL BRANCH : IIIrd Auditorium
- EXPERIMENTAL STUDY OF MYOCARDIAL INFARCTION THROUGH THE USE OF BODY SURFACE ISOPOTENTIAL MAPS. : LIGATION OF THE ANTERIOR DESCENDING BRANCH OF THE LEFT CORONARY ARTERY : Ist Auditorium : PROCEEDINGS OF THE 40TH ANNUAL MEETING OF THE JAPANESE CIRCULATION S
- EPICARDIAL ACTIVATION PATTERNS AND DISPERSION OF REFRACTORINESS INITIATING VENTRICULAR TACHYCARDIA IN THE CANINE LEFT VENTRICLE DURING ACUTE ISCHEMIA
- BODY SURFACE ISOPOTENTIAL MAPS IN NORMAL CHILDREN : Mapping : 46th Annual Scientific Meeting, Japanese Circulation Society
- DISPERSION OF EFFECTIVE REFRACTORY PERIOD IN THE ISCHEMIC BORDER ZONE IN CANINE HEART : Arrhythmia : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- -296-EFFECTS OF CARDIAC GLYCOSIDE ON ATRIOVENTRICULAR CONDUCTION AND INTERCELLULAR ELECTRICAL COUPLING : Cardiotonics : PROCEEDINGS OF THE 42nd ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Angiotensin-converting Enzyme Inhibitor Cilazapril Suppresses Expression of Basic Fibroblast Growth Factor Messenger Ribonucleic Acid and Protein in Endothelial and Intimal Smooth Muscle Cells in a Vascular Injury Model of Spontaneous Hypertensive Rats
- Quasigeostrophic Confocal Spheroidal Vortices
- Quasigeostrophic Confocal Spheroidal Vortices
- Counter-Rotating Quasigeostrophic Ellipsoidal Vortex Pair
- Counter-Rotating Quasigeostrophic Ellipsoidal Vortex Pair
- Lipocalin-type prostaglandin D synthase (beta-trace) in cerebrospinal fluid : a useful marker for the diagnosis of normal pressure hydrocephalus
- 12)RELATIONSHIP AMONG THE ECG, THE VCG AND THE BODY SURFACE ISO-POTENTIAL MAPS IN PATIENTS WITH RIGHT BUNDLE BRANCH BLOCK : THE II CONFERENCE ON VECTORCARDIOGRAPHY
- DIAGNOSIS OF HIGH POSTERIOR INFARCTION THROUGH THE USE OF BODY SURFACE ISOPOTENTIAL MAPS : IVth Auditorium
- Magnetohydrodynamic Stability of Spheromak Plasma in Toroidal Flux Conserver with Rectangular Cross Section.II.Application of Mercier Criterion
- Magnetohydrodynamic Stability of Spheromak Plasma in Toroidal Flux Conserver with Rectangular Cross Section
- Magnetohydrodynamic Equilibrium and Stability of Spheromak Plasma in Flux Conserver
- Magnetohydrodynamic Equilibrium and Stability of Spheromak Plasma in Flux Conserver
- Extension of Measurable Region of Object Vibration Phasor in Phase-Modulated TV Holographic Interferometry : Experiment
- EFFECT OF SYMPATHETIC STIMULATION ON VENTRICULAR REFRACTORINESS DURING ISCHEMIA : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Arrhythmia
- ANTAGONISTIC EFFECT OF ACETYLCHOLINE TO ISOPROTERENOL ON EFFECTIVE REFRACTORY PERIODS OF GUINEA-PIG PAPILLARY MUSCLES : Electrophysiology : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- ELECTROPHYSIOLOGICAL MECHANISMS OF REPERFUSION ARRHYTHMIAS : ENDOCARDIAL MAPPING STUDY IN ISOLATED CORONARY : PERFUSED DOG HEARTS : Ischemic Heart Disease (II) : FREE COMMUNICATIONS (II) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE
- EFFECTS OF SYMPATHETIC ACTIVITY ON THE VENTRICULAR TACHYCARDIA IN ONE-DAY-OLD MYOCARDIAL INFARCTION IN THE DOG : Arrhythmias (II), Electrophysiology (II), Mapping : III : 48 Annual Scientific Meeting, Japanese Circulation Society
- VARIABILITY OF QRST AREA MAPS WITH VARIED ACTIVATION SEQUENCE IN NORMAL AND INFARCTIONAL DOGS : Electrocardiography : I : 48 Annual Scientific Meeting, Japanese Circulation Society
- BODY SURFACE ISOPOTENTIAL MAPS IN OLD ANTERIOR MYOCARDIAL INFARCTION UNDETECTABLE BY 12 LEAD ELECTROCARDIOCRAMS : Electrocardiography : I : 48 Annual Scientific Meeting, Japanese Circulation Society
- BODY SURFACE MAP AND VECTORCARDIOGRAPHIC CORRELATION IN OLD INFERIOR MYOCARDIAL INFARCTION UNDETECTABLE BY 12 LEAD ELECTROCARDIOGRAM : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Vectorcardiography Mapping
- Brief exposure to hypoxia induces bFGF mRNA and protein and protects rat cortical neurons from prolonged hypoxic stress
- Symptomatic Hemorrhage Associated With Recurrent Pilocytic Astrocytoma With Granulation Tissue : Case Report
- Unusual Progression of Pleomorphic Adenoma of the Lacrimal Gland
- Immunoreactivity of recombinant human ADP-ribosylarginine hydrolase
- Identification of a 27.5 kDa, thiol-independent arginine-specific adenosine diphosphate(ADP)-ribosyltransferase in chicken bone marrow cells
- Arginine-Specific ADP-Ribosyltransferase on the Surface of Gizzard Smooth Muscle Cells and the Involvement of Phosphatidylinositol 3-Kinase in Maintaining the Activity of This Transferase
- Involvement of Hypoxia-Inducible Factor-1α and Vascular Endothelial Growth Factor in the Mechanism of Development of Chronic Subdural Hematoma
- Glossopharyngeal Neuralgia Treated by Microvascular Decompression : Case Report
- Compatibility of Polyether Sulfone and Polymide Derived from Isomerization of Polysoimide. An Approach to In-Situ Generated Rigid-Rod Molecular Composite
- In situ Formed Three Layer Film by Isomerization of Fluorinated Polyisoimide in Polyethersulfone as a Matrix Polymer
- Sound Propagation in Bismuth under Strong Magnetic Field. II
- Sound Propagation in Semimetals under Stroug Magnetic Field
- Effectiveness of herbal medicine (Rokumigan and Hachimijiogan) for fatigue or loss of energy in patients with partial remitted major depressive disorder
- Clinical efficacy of tandospirone augmentation in patients with major depressive disorder : A randomized controlled trial
- Herbal medicine in the treatment of fluvoxamine-induced nausea and dyspepsia
- Use of herbal medicine for treating psychiatric disorders in Japan
- Effectiveness of nilvadipine in two cases of chronic schizophrenia
- Analysis of Bile Acids in Urine Specimens from Healthy Humans: Detrmination of Several Bile Acids with β-Hydroxyl and Carbonyl Groups
- Neurodegeneration of substantia nigra accompanied with macrophage/microglia infiltration after intrastriatal hemorrhage
- DETECTION OF THE SITE OF CONDUCTION DISTURBANCE IN THE SURGICALLY INDUCED RIGHT BUNDLE BRANDLE BRANCH BLOCK USING BODY SURFACE ISOPOTENTIAL MAPS : Electrocardiography : IInd Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation S
- Remark on the Kinetic Equation in an Unstable Plasma
- A NEW STATISTICAL METHOD FOR SOLVING THE INVERSE PROBLEM IN ELECTROCARDIOGRAPHY : Mapping : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- Chronic, Traumatic Intraconal Hematic Cyst of the Orbit Removed Through the Fronto-orbital Approach : Case Report
- Correlation between Body Surface Isopotential Maps and Left Ventriculograms in Patients with Old Anterior Myocardial Infarction
- Effect of Antileukocyte Adhesion Molecule Antibodies, Nitric Oxide Synthase Inhibitor, and Corticosteroids on Endotoxin Shock in Mice
- Protection by Polaprezinc, an Anti-ulcer Drug, Against Indomethacin-Induced Apoptosis in Rat Gastric Mucosal Cells
- Effects of Hypoxia on Conduction Velocity of Ventricular Muscle
- Simultaneous measurement of tryptophan and related compounds by liquid chromatography/electrospray ionization tandem mass spectrometry
- Dynamics of Longitudinal Component in Ordered Spin Systems
- Critical Dynamics of Longitudinal Component in Ordered Spin System
- EFFECTS OF ACETYLCHOLINE (ACh) ON THE SINOATRIAL NODE CELLS OF THE RABBIT HEARTS IN THE HYPOXIA : Arrhythmia I, Immunity & Heredity, Contractile Protein : IVth Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Tokyo,
- Mechanisms of Protection by S-Allylmercaptocysteine Against Acetaminophen-Induced Liver Injury in Mice
- Ginseng enhances contextual fear conditioning and neurogenesis in rats
- EFFECTS OF OUABAIN ON ELECTRICAL COUPLING OF RABBIT ATRIAL MUSCLE FIBERS
- Velocity Correlation Function of Electron Interacting with Impurity Centers in Two Dimensions
- Pure Amnesia Caused by Bilateral Temporal Lobe Astrocytoma : Case Report
- Knudsen Flow and Effective Shear Viscosity of Liquid ^3He : I. QUANTUM LIQUIDS AND SOLIDS : Superfluid Flow
- Effects of Beta-Adrenergic Blocking Drug Pindolol (LB46) on Cardiac Fibers in Relation to Its Membrane Effects
- An association study between a transcriptional polymorphism in the serotonin transporter gene and panic disorder in a Japanese population
- Crossover between Cooper-Pair Condensation and Bose-Einstein Condensation of "Di-Electronic Molecules" in Two-Dimensional Superconductors
- A Self-Consistent Theory of the Pair Fluctuations in the Two-Dimensional Fermi Superfluidity
- Subarachnoid Hemorrhage Induces Na^+/myo-Inositol Cotransporter in the Rat Brain
- Growth of Occult Arteriovenous Malformation After Cerebral Hemorrhage Demonstrated by Serial Magnetic Resonance Imaging