Subarachnoid Hemorrhage Induces Na^+/myo-Inositol Cotransporter in the Rat Brain
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概要
- 論文の詳細を見る
Neurons and glial cells respond to extracellular hyperosmolarity by accumulating small organic solutes, called "osmolytes." Na^+/myo-inositol is one of the major organic osmolytes in the brain and Na^+/myo-inositol cotransporter (SMIT) regulates extracellular Na^+/myo-inositol content. Subarachnoid hemorrhage (SAH) is an osmotic stress-inducing event of the brain. The expression of SMIT messenger ribonucleic acid (mRNA) and protein was investigated with in situ hybridization and immunohistochemistry in rat brains with SAH induced by endovascular perforation. SMIT riboprobe was raised from a 490-bp rat SMIT complementary deoxyribonucleic acid. Anti-SMIT antibody was raised in rabbits. SMIT mRNA was expressed strongly in the cortex, hippocampus, and hypothalamus of the perforated side at 6 to 24 hours after SAH. Mild upregulation was noted in the contralateral cortex, hippocampus, and hypothalamus. The ventral aspect of the pons showed mild upregulation. Microautoradiography and immunostaining showed SMIT expression mainly in the neurons, but also in some non-neural cells in the hippocampus. The present results indicate that diffuse osmotic stress occurs in the host brain after SAH.
- 日本脳神経外科学会の論文
- 2003-02-15
著者
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YAMADA Kazuo
Department of Biochemistry, Faculty of Medicine, Shimane University
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Masago Atsuo
Department Of Neurosurgery Internal Medicine And Pathology Toyokawa City Hospital:department Of Neur
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Masago Atsuo
Department Of Neurosurgery Nagoya City University Medical School
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KIMURA Tomohiro
Department of Electrical and Electronic Engineering, Tokyo Institute of Technology
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Shimada Syoichi
Department Of Molecular Morphology Nagoya City University Medical School
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Kimura Tomohiro
Department Of Electrical And Electronic Engineering Tokyo Institute Of Technology
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Kimura Tomohiro
Department Of Neurosurgery Nagoya City University Medical School
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Yamada Kazuo
Department Of Biochemistry Faculty Of Medicine Shimane University
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Yamada Kazuo
Department Of Neurosurgery Nagoya City University Medical School
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Yamada Kazuo
Department Of Architecture Faculty Of Engineering Aichi Institute Of Technoligy
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Yamada Kazuo
Department of Applied Molecular Chemistry, College of Industrial Technology, Nihon University
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