Increased numbers of oligodendrocyte lineage cells in the optic nerves of cerebroside sulfotransferase knockout mice
スポンサーリンク
概要
- 論文の詳細を見る
Sulfatide is a myelin glycolipid that functions in the formation of paranodal axo-glial junctions in vivo and in the regulation of oligodendrocyte differentiation in vitro. Cerebroside sulfotransferase (CST) catalyzes the production of two sulfated glycolipids, sulfatide and proligodendroblast antigen, in oligodendrocyte lineage cells. Recent studies have demonstrated significant increases in oligodendrocytes from the myelination stage through adulthood in brain and spinal cord under CST-deficient conditions. However, whether these result from excess migration or in situ proliferation during development is undetermined. In the present study, CST-deficient optic nerves were used to examine migration and proliferation of oligodendrocyte precursor cells (OPCs) under sulfated glycolipid-deficient conditions. In adults, more NG2-positive OPCs and fully differentiated cells were observed. In developing optic nerves, the number of cells at the leading edge of migration was similar in CST-deficient and wild-type mice. However, BrdU+ proliferating OPCs were more abundant in CST-deficient mice. These results suggest that sulfated glycolipids may be involved in proliferation of OPCs in vivo.(Communicated by Kunihiko SUZUKI, M.J.A.)
著者
-
Ikenaka Kazuhiro
Division Of Neurobiology And Bioinformatics National Institute For Physiological Sciences
-
Tanaka Kenji
Division Of Surgical Oncology Department Of Translational Medical Sciences Nagasaki University Gradu
-
Baba Hiroko
Department Of Molecular Neurobiology Tokyo University Of Pharmacy And Life Science
-
Hayashi Akiko
Department Of Biological And Environmental Science Faculty Of Agriculture Kobe University:(present A
-
Ishibashi Tomoko
Department Of Anesthesiology Graduate School Of Medicine Tokyo Medical And Dental University
-
KAJIGAYA Hitoshi
Department of Molecular Neurobiology, School of Pharmacy, Tokyo University of Pharmacy and Life Scie
-
SUZUKI Ayaka
Department of Molecular Neurobiology, School of Pharmacy, Tokyo University of Pharmacy and Life Scie
-
KAJIGAYA Hitoshi
Department of Molecular Neurobiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
-
HAYASHI Akiko
Department of Molecular Neurobiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
-
SUZUKI Ayaka
Department of Molecular Neurobiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
-
ISHIBASHI Tomoko
Department of Molecular Neurobiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
-
TANAKA Kenji
Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences
関連論文
- Giant hemangioma of the fetal neck, mimicking a teratoma
- Alteration of Brain Type N-Glycans in Neurological Mutant Mouse Brain
- Intraductal papillary neoplasm of the bile duct extending superficially from the intrahepatic to extrahepatic bile duct
- Modified Japan Integrated Staging is currently the best available staging system for hepatocellular carcinoma patients who have undergone hepatectomy
- Immunohistochemical analysis of tumor biological factors in hepatocellular carcinoma : relationship to clinicopathological factors and prognosis after hepatic resection
- Genetic analysis of radiation-associated rectal cancer
- P-IS-96 The polyamine and proline pathway in initiation and development of intimal hyperplasia in premenopausal human uterine arteries(Others 2,Group 112,International Session)
- Mineralogy and petrology of chondrule in Ouallen (Tanezrouft) meteorite
- Glycoproteomic analysis of abnormal N-glycosylation on the kappa chain of cryocrystalglobulin in a patient of multiple myeloma
- Conduction properties of identified neural pathways in the central nervous system of mice in vivo
- Changes in the expression of E-cadherin repressors, Snail, Slug, SIP1, and Twist, in the development and progression of ovarian carcinoma : the important role of Snail in ovarian tumorigenesis and progression
- Overexpression of RhoA enhances peritoneal dissemination: RhoA suppression with Lovastatin may be useful for ovarian cancer
- Microarray analysis of embryonic retinoic acid target genes in the ascidian Ciona intestinalis
- Effectiveness of Polyclonal and Monoclonal Antibodies Prepared for an Immunoassay of the Etofenprox Insecticide
- Elevated Maternal Serum Folate in the Third Trimester and Reduced Fetal Growth: A Longitudinal Study
- Massive cystic lymphangiomas of a fetus
- Two cases of a fetus with sirenomelia sequence
- High Titer Retroviral Gene Transduction to Neural Progenitor Cells for Establishment of Donor Cells for Neural Transplantation to Parkinsonian Model Rats
- Congenital intrathoracic kidney with right Bochdalek defect
- An Analysis of Image Request Arrival Patterns from Image Display Terminals of PACS in a Large Scale Hospital
- Increased numbers of oligodendrocyte lineage cells in the optic nerves of cerebroside sulfotransferase knockout mice
- Reversible cerebral vasoconstriction syndrome with limb myoclonus following intravenous administration of methylergometrine
- Late Radiation Injury of the Large Intestine : Colonoscopic Findings in 103 Cases
- Primary Bile Duct Cystadenocarcinoma with Direct Invasion to the Gastric Wall
- Factors Influencing Proper Clinical Evaluation of Depth of Tumor Invasion in Gastric Cancer
- Elevated Maternal Serum Folate in the Third Trimester and Reduced Fetal Growth : A Longitudinal Study