Elevated Maternal Serum Folate in the Third Trimester and Reduced Fetal Growth: A Longitudinal Study
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概要
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This study aimed to examine the association of fetal growth and elevated third trimester maternal serum folate due to folic acid (FA) supplement intake. Dietary intake, use of FA supplements, weight, and blood biomarkers of B-vitamins (serum folate, pyridoxal, vitamin B12, and plasma total homocysteine) were observed in 33 healthy pregnant women at the third trimester (average gestational age 35 wk). Birth outcomes were assessed through hospital birth records. Infant anthropometry and maternal blood biomarkers were followed up at 1 mo postpartum. Fourteen women were taking FA supplements at the third trimester. Dietary intake was similar among FA users and non-users, but serum folate and pyridoxal were significantly higher in users (11.6±6.7 vs. 6.1±3.2 ng/mL, and 13.8±21.7 vs. 3.2±1.4 ng/mL, respectively). Plasma total homocystein (tHcy) was higher in non-users compared to users, but not significantly. Nine FA users and eight non-users had low serum vitamin B12 values (<203 pg/mL). Nine FA users and all non-users had low serum pyridoxal values (<7.0 ng/mL). Infant birthweight was significantly lower in users compared to non-users (2,894±318 vs. 3,154±230 g). At 1 mo postpartum, infant weight and length were similar between FA users and non-users, but infant weight gain was larger in users. Higher serum folate values due to FA use in the third trimester was related to reduced fetal size. Excess FA under low vitamin B6 and B12 status may affect fetal growth.
著者
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Kubota Toshiro
Department Of Comprehensive Reproductive Medicine Graduate School Tokyo Medical And Dental Universit
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Kusama Kaoru
Department Of Dental Pharmacology Meikai University School Of Dentistry
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YOSHIIKE Nobuo
Department of Epidemiology, Medical Research Institute, Tokyo Medical and Dental University
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Kato Noriko
Department Of Education And Training Technology Development National Institute Of Public Health
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Miyasaka Naoyuki
Department Of Comprehensive Reproductive Medicine Graduate School Tokyo Medical And Dental Universit
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Ishibashi Tomoko
Department Of Biology Faculty Of Science Kochi University
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Takimoto Hidemi
Department Of Health Promotion And Research National Institute Of Public Health
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HAYASHI Fumi
Department of Nutrition, Chiba Prefectural University of Health Sciences
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TOBA Mikayo
Department of Obstetrics and Gynecology, Tokyo Medical and Dental University
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Ishibashi Tomoko
Department Of Anesthesiology Graduate School Of Medicine Tokyo Medical And Dental University
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