Inhibitory Effects of Magnoshinin and Magnosalin, Compounds from "Shin-i" (Flos Magnoliae), on the Competence and Progression Phases in Proliferation of Subcultured Rat Aortic Endothelial Cells.
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概要
- 論文の詳細を見る
Anti-proliferative effects of magnoshinin and magnosalin derived from "<I>Shin-i</I>" (<I>Flos magnoliae</I>) were investigated using subcultured endothelial cells (EC) of rat aorta. The inhibitory effects of magnoshinin were 2-fold greater at 10 μg/ml than that of magnosalin on the increase in cell number when EC were stimulated by 5% fetal bovine serum. In the <SUP>3</SUP>H-thymidine incorporation monitored at 3 hr-intervals, magnoshinin (0.1-3 μg/ml) prolonged the starting time of DNA synthesis and reduced the rate of incorporation into EC. Magnosalin (0.3-3 μg/ml) reduced only the incorporation rate. These results suggest that magnoshinin inhibits both the competence phase and progression phase, but magnosalin preferentially inhibits the progression phase in EC proliferation.
- 公益社団法人 日本薬理学会の論文
著者
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Kobayashi Shinjiro
Department Of Chemical Pharmacology Toyama Medical And Pharmaceutical University
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Kimura Masayasu
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Kimura Ikuko
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Kobayashi Shinjiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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Nagaura Takeshi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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