Blocking effects of a new component, paeoniflorigenone, in paeony root on neuromuscular junctions of frogs and mice.
スポンサーリンク
概要
- 論文の詳細を見る
A new monoterpene, paeoniflorigenone (PFG) (100-900 μg/ml), which was isolated from paeony roots and identified chemically, suppressed both indirectly and directly stimulated muscle twitchings of frog sciatic nerve-sartorius muscle preparation, and it indirectly stimulated muscle twitchings of phrenic nerve-diaphragm muscle preparations. The suppression effect by PFG (300 μg/ml) on twitching was not reversed by neostigmine (60 μg/ml) and was restored by washing out of PFG. PFG (150 μg/ml) depolarized the diaphragm muscle membranes by 10 mV and did not change the electrotonic potentials. PFG (100 μg/ml) inhibited weakly acetylcholine (5 μg/ml)-induced slow contractions. These results demonstrated that PFG is a depolarizing neuromuscular blocking agent, being similar to succinylcholine, except that PFG did not produce any contraction, but succinylcholine did.
- 公益社団法人 日本薬理学会の論文
著者
-
Takahashi Kazuyoshi
Department Of Cardiology Niigata City General Hospital
-
Nojima Hiroshi
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
-
Hayashi Toshimitsu
Department Of Architecture School Of Science And Engineering Kinki University
-
Kimura Masayasu
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
-
Morita Naotaka
Department Of Medicinal Resources Faculty Of Pharmaceutical Sciences Toyama Medical & Pharmaceut
-
Kimura Ikuko
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
-
HAYASHI Toshimitsu
Departments of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
-
SHIMIZU Mineo
Departments of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
-
KIMURA Ikuko
Departments of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
-
KIMURA Masayasu
Departments of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
-
NOJIMA Hiroshi
Departments of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
関連論文
- Improved cardiac function after sirolimus-eluting stent placement in diabetic patients by pioglitazone : Combination therapy with statin
- OJ-093 Appropriate Cutoff Value of Waist Circumference is Influenced by Age and BMI : Analysis of 68,785 Adults in Health-check Examination(OJ16,Metabolic Syndrome (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circula
- A chronic myeloid leukemia patient with atypical karyotype and BCR-ABL e13a3 transcript caused by complex chromosome rearrangement
- Effect of Cibenzoline and Atenolol Administration on Dynamic Left Ventricular Obstruction Due to Sigmoid-Shaped Septum
- Health-Related Quality of Life of Outpatients With Systolic and Isolated Diastolic Dysfunction : Sado Heart Failure Study
- Characterization of Outpatients With Isolated Diastolic Dysfunction and Evaluation of the Burden in a Japanese Community : Sado Heart Failure Study
- A Mouse Model of Sural Nerve Injury-Induced Neuropathy : Gabapentin Inhibits Pain-Related Behaviors and the Hyperactivity of Wide-Dynamic Range Neurons in the Dorsal Horn
- Intracisternal, But Not Intrathecal, Injection of Naloxone Inhibits Cutaneous Itch-Related Response in Mice(Pharmacology)
- Endovascular Stent-Grafting for Recurrent Aneurysm in Behcets Disease
- Pharmacokinetic and pharmacodynamic analysis of cyclosporine A (CsA) to find the best single time point for the monitoring and adjusting of CsA dose using twice-daily 3-h intravenous infusions in allogeneic hematopoietic stem cell transplantation
- Characterization of Outpatients With Systolic Dysfunction in a Japanese Community by Total Enumeration : Sado Heart Failure Study
- PJ-213 Impact of Exercise Capacity on the Quality of Life in Patients with Diastolic Dysfunction : Niigata Sado Heart Failure Study(Heart failure, clinical-16 (M) PJ36,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanes
- PJ-061 Relation between Quality of Life and Clinical Parameters in Patients with Systolic Dysfunction Niigata Sado Heart Failure Study(Heart failure, clinical-19 (M) PJ11,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japa
- DESENSITIZING NEUROMUSCULAR BLOCKADE BY p-PHENYLENE-POLYMETHYLENE BIS-AMMONIUM COMPOUNDS DEVELOPED FROM SUCCINYLCHOLINE
- Imatinib Mesilate Inhibits Neointimal Hyperplasia via Growth Inhibition of Vascular Smooth Muscle Cells in a Rat Model of Balloon Injury
- Bridging Collateral from an Internal Mammary Arterial Graft to a Coronary Artery
- Gene therapy on EAM with pCAGGS plasmid encoding SLPI/IgG_1Fc chimera
- Evidence for Separate Involvement of Different μ-Opioid Receptor Subtypes in Itch and Analgesia Induced by Supraspinal Action of Opioids
- Pharmacological Evaluation of Morphine and Non-opioid Analgesic Adjuvants in a Mouse Model of Skin Cancer Pain(Pharmacology)
- Possible Involvement of 5-Lipoxygenase Metabolite in Itch-Associated Response of Mosquito Allergy in Mice
- Repeated Treatment With the Traditional Medicine Unsei-in Inhibits Substance P-Induced Itch-Associated Responses Through Downregulation of the Expression of Nitric Oxide Synthase 1 in Mice
- Inhibitory Effect of the Repeated Treatment with Unsei-in on Substance P-Induced Itch-Associated Responses through the Downregulation of the Expression of NK_1 Tachykinin Receptor in Mice
- Suppression by Gabapentin of Pain-Related Mechano-Responses in Mice Given Orthotopic Tumor Inoculation
- Inhibitory Effect of Azelastine on Allergic Itch-Associated Response in Mice Sensitized With Mosquito Salivary Glands Extract
- Serum Hepcidin-20 is Elevated during the Acute Phase of Myocardial Infarction
- PJ-525 MPO and MPO-ANCA in Coronary Artery Circulation(PJ088,ACS/AMI (Clinical/Pathophysiology) 2 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- A Mouse Model of Sural Nerve Injury–Induced Neuropathy: Gabapentin Inhibits Pain-Related Behaviors and the Hyperactivity of Wide-Dynamic Range Neurons in the Dorsal Horn
- 2 Evaluation of the Prospective Observation of Erythropoietin-Administration for the Treatment of Acute Myocardial Infarction (EPO-AMI)(Late Breaking Clinical Trials II,The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-034 The Association Between the Type of Cardiac Dysfunction and Hospitalization Due to Congestive Heart Failure(Heart failure, clinical-01, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Elderly Patients with Systolic Dysfunction in the Community (Niigata-Sado Heart Failure Study) (Heart Failure, Clinical 16 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Approximate Prevalence of Diastolic Dysfunction in the Community (Niigata-Sado Heart Failure Study) (Heart Failure, Clinical 16 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Burden of Systolic and Diastolic Ventricular Dysfunction in the Community (Preventive Medicine/Epidemiology/Education/Health Policy 6 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-623 Long-Term Change of Renal Function in Japanese Patients with Idiopathic Dilated Cardiomyopathy(Heart failure, clinical-16, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-083 Mechanical Alternans is a Possible Linker between Heart Failure and Ventricular Fibrillation(Heart failure, clinical-05, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-458 Serum Endostatin in the Coronary Circulation of Patients with Coronary Heart Disease and Its Relation to Coronary Collateral Formation(Coronary circulation, basic/clinical-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- A case of intracoronary protruded thrombus caused after bailout stenting for side branch occlusion
- Dynamic Intraventricular Obstruction in Acute Myocardial Infarction With Administration of Cilostazol
- PJ-767 Effects of Pioglitazone on Cardiac Function after PCI with DES : Effects of Combination Therapy with Statin(Diabetes/Obesity/Metabolic syndrome-11, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-204 Blood Pressure and Cardiovascular Events in the Outpatients with Systolic Dysfunction : Niigata Heart Failure Study(Heart failure, clinical-11 (M) PJ34,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circula
- PJ-065 An Epidemic of Systolic Heart Failure is being Realizing in an Urban Area in Japan Niigata-Sado Heart Failure Study(Heart failure, clinical-19 (M) PJ11,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Ci
- Aortocoronary Dissection Resolved by Coronary Stenting Guided by Intracoronary Ultrasound
- PJ-476 Clinical Outcomes of Left Main Trunk Percutaneous Revascularization : Our Experience(Coronary Revascularization, PTCA/Stent/DCA/Rotablator/New Device 12 (IHD) : PJ79)(Poster Session (Japanese))
- PJ-096 Coronary angioplasty of chronic total occlusions : long-term clinical follow-up(Coronary Revascularization, PTCA/Stent/DCA/Rotablator/New Device 3 (IHD) : PJ16)(Poster Session (Japanese))
- Highly Vascular Pelvic Tumor Causing High-Output Heart Failure Because of Massive Arteriovenous Shunting : A Case Report
- Th1/Th2 Balance Alteration in the Clinical Course of a Patient With Acute Viral Myocarditis
- Antipruritic Effects of the Supercritical Fluid Extract from Cnidii monnieri fructus (dried fruits of Cnidium monnieri CUSSON) in Mice
- Roles of α-Adrenoceptors and Sympathetic Nerve in Acute Herpetic Pain Induced by Herpes Simplex Virus Inoculation in Mice
- Mechanical Hypersensitivity and Alterations in Cutaneous Nerve Fibers in a Mouse Model of Skin Cancer Pain
- Effects of Naltrexone on Spontaneous Itch-Associated Responses in NC Mice With Chronic Dermatitis
- Aconitine, a Main Component of Aconite, Increases Spontaneous Acetylcholine Release from the Frontal Cerebral Cortex of Freely Moving Rats
- ACETYLCHOLINE RECEPTOR-OPERATED INTRACELLULAR CALCIUM MOBILIZATION MODIFIED BY DIABETIC STATE IN SKELETAL MUSCLE
- HYPERSENSITIVITY OF ACETYLCHOLINE RECEPTOR IN DIABETIC SKELETAL MUSCLE TO NEUROMUSCULAR BLOCKERS : THE EFFECT ON MYOTUBES CULTURED WITH SPINAL CORD OR ITS EXTRACT
- Relationship Between Insulin-Like Growth Factor-I and Brain Natriuretic Peptide in Patients With Acromegaly After Surgery
- Algogenic effects of Extract of the Tumor Mass Isolated from Mice with Orthotopic Melanoma Inoculation
- Angiopoietin-1, Angiopoietin-2 and Tie-2 in the Coronary Circulation of Patients With and Without Coronary Collateral Vessels
- Plasma Concentrations of Cytokines and Neurohumoral Factors in a Case of Fulminant Myocarditis Successfully Treated With Intravenous Immunoglobulin and Percutaneous Cardiopulmonary Support
- Relation between mechanical alternans and ST-T electrical alternans in patients with chronic heart failure
- Roles of Mast Cells and Histamine in Mosquito Bite-Induced Allergic Itch-Associated Responses in Mice
- PJ-731 Parameters to Represent Impaired Force-frequency Relationship in Patients with Chronic Heart Failure(Cardiac function, basic/clinical-5 (M) PJ124,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation S
- PJ-193 Relation between Mechanical Restitution Property and Left Ventricular Systolic Function in Patients with Chronic Heart Failure(Heart failure, basic-6 (M) PJ33,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese
- OE-213 Evaluation of Adipocytokines, Proinflammatory Cytokines, and Inflammatory Markers in Coronary Sinus and Hepatic Venous Blood(Coronary circulation, basic/clinical-1 (IHD) OE36,Oral Presentation (English),The 70th Anniversary Annual Scientific Meetin
- OE-221 Role of Cardiac Resynchronization Therapy on Renal Function(Kidney/Renal circulation(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Itch-Associated Response Induced by Experimental Dry Skin in Mice
- Intradermal Cholinergic Agonists Induce Itch-Associated Response via M_3 Muscarinic Acetylcholine Receptors in Mice
- Characterization of itch-associated responses of NC mice with mite-induced chronic dermatitis
- Itch-Associated Responses of Afferent Nerve Innervating the Murine Skin: Different Effects of Histamine and Serotonin in ICR and ddY Mice
- Induction by carrageenan inflammation of prepronociceptin mRNA in VR1-immunoreactive neurons in rat dorsal root ganglia
- Pharmacological and Immunohistochemical Characterization of a Mouse Model of Acute Herpetic Pain
- RECS1 is a Negative Regulator of Matrix Metalloproteinase-9 Production and Aged RECS1 Knockout Mice are Prone to Aortic Dilation(EXPERIMENTAL INVESTIGATION)
- RECS1 deficiency in mice induces susceptibility to cystic medial degeneration
- Structure, Expression and Chromosome Mapping of MLZE, a Novel Gene Which Is Preferentially Expressed in Metastatic Melanoma Cells
- Annexin VII as a Novel Marker for Invasive Phenotype of Malignant Melanoma
- PJ-459 Angiopoietin-1, Angiopoietin-2 and Tie-2 in the Coronary Circulation of Patients with and without Coronary Collateral Vessels(Coronary circulation, basic/clinical-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Isolation of Flat Revertants from Human Papillomavirus Type 18 E6E7 Transformed 3Y1 Cells by Transfection with a Rat Embryo Fibroblast cDNA Expression Library
- Enhancement of Anti-tumor Cytotoxicity of Expanded γδ T Cells by Stimulation with Monocyte-derived Dendritic Cells
- A Large Scale Isolation of cDNAs Responsive to Shear Stress from Cultured Human Endothelial Cells
- Ischemic Heart Diseases with Systolic Dysfunction in the Community (Niigata-Sado Heart Failure Study)(Myocardial Ischemia-reperfusion, Clinical 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Cerebrovascular Diseases are an Independent Predictor of Death for Systolic Dysfunction Patients (Niigata-Sado Heart Failure Study)(Cerebrovascular Circulation/Stroke 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Relation Between Renal Dysfunction and Heart Failure in the Community (Niigata-Sado Heart Failure Study)(Kidney/Renal Circulation 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-232 Linkage between Mechanical And Electrical Alternans in Patients with Chronic Heart Failure(Heart Failure, Clinical 3 (M) : PJ39)(Poster Session (Japanese))
- In Vitro Examination of the Safety of Rotational Atherectomy of Side Branches Jailed by Stents
- Successful All-trans Retinoic Acid Treatment of Acute Promyelocytic Leukemia in a Patient with NPM/RAR Fusion
- Aconitine Induces Bradycardia through a Transmission Pathway Including the Anterior Hypothalamus in Conscious Mice
- Serotonin-induced Biting of the Hind Paw is Itch-related Response in Mice
- Inhibition of Itch-Scratch Response by Fruits of Cnidium monnieri in Mice
- The Saccharomyces cerevisiae bud-neck proteins Kcc4 and Gin4 have distinct but partially-overlapping cellular functions
- A Novel Program to Accurately Quantify Infarction Volume by ^Tc MIBI SPECT, and Its Application for Re-Analyzing the Effect of Erythropoietin Administration in Patients With Acute Myocardial Infarction : A Randomized Controlled Pilot Trial of the EPO
- Acetylcholine-Induced Biphasic Effect on the Maximum Upstroke Velocity of Action Potential in Mouse Right Atria : Interaction With β-Adrenergic Signaling Cascade
- Endothelium-Dependent Potentiation of Prostaglandin F_Induced Contractions by (±)-[6]-Gingerol Is Inhibited by Cyclooxygenase- but Not Lipoxygenase-Inhibitors in Mouse Mesenteric Veins
- -359-ALCOHOLIC CARDIOMYOPATHY : DIRECT AND INDIRECT EFFECTS OF ACETALDEHYDE
- PE-431 Increased in vivo Myocardial Uptake of Adenovirus in Rat Experimental Autoimmune Myocarditis(Myocarditis, basic/clinical-2 (M) PE72,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- An Application of Vasconcelos' Lemma
- Two-wire protection of side branches to prevent side branch occlusion during stent implantation for bifurcational lesions
- Clinical value of assessing the response to imatinib monitored by interphase FISH and RQ-PCR for BCR-ABL in peripheral blood for long-term survival of chronic phase CML patients : results of the Niigata CML-multi-institutional co-operative clinical study
- Features of Japanese patients with myelodysplastic syndrome in an aging population of Sado Island
- Single-Dose Intravenous Administration of Recombinant Human Erythropoietin Is a Promising Treatment for Patients With Acute Myocardial Infarction : Randomized Controlled Pilot Trial of EPO/AMI-1 Study
- Blocking effects of blended paeoniflorin or its related compounds with glycyrrhizin on neuromuscular junctions in frog and mouse.
- Blocking effects of a new component, paeoniflorigenone, in paeony root on neuromuscular junctions of frogs and mice.
- The Fluorine, Chlorine, Bromine, and Iodine Contents of Volcanic Rocks in Japan
- The Relation between the Volatilization Rates of Chlorine and Bromine Compounds from Volcanic Rocks on Heating