Intradermal Cholinergic Agonists Induce Itch-Associated Response via M_3 Muscarinic Acetylcholine Receptors in Mice
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概要
- 論文の詳細を見る
In the present study, we examined whether cholinergic agonists would elicit an itch-associated response in mice. When mice were given an intradermal injection of carbachol (1 – 10 nmol) or bethanechol (0.3 – 100 nmol) into the rostral back, they showed the dose-dependent increase of scratching. Nicotine (1 – 10 nmol) showed no effect. Pretreatment with naloxone, but not with terfenadine, significantly suppressed the carbachol-induced scratching. When intradermally co-injected with carbachol, atropine and 4-DAMP but neither methoctramine nor pancuronium significantly inhibited the carbachol-induced scratching. Muscarinic agonists are suggested to produce itch through activation of M3 muscarinic receptors in the skin.
- 社団法人 日本薬理学会の論文
- 2002-03-01
著者
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NOJIMA Hiroshi
Department of Pharmacology, School of Pharmaceutical Sciences, Ohu University
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KURAISHI Yasushi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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Kuraishi Yasushi
富山大学 医学薬学研究部応用薬理学
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Nojima H
Department Of Pharmacology School Of Pharmaceutical Sciences Ohu University
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Nojima Hiroshi
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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MIYAMOTO Takayuki
Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceu
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Nojima Hiroshi
Faculty Of Horticulture Chiba University
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Nojima Hiroshi
Department Of Molecular Generics Research Institute For Microbial Diseases Osaka University
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Kuraishi Yasushi
Department Of Applied Pharmacology Faculty Of Pharmaceu Tical Sciences
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Miyamoto Takayuki
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Kuraishi Yasushi
Department Of Applide Biochemistry Research Institute For Wakan-yaku Toyama Toyama Medical And Pharm
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