The External Ca2+-Dependence of Acetylcholine-Induced Contracture in Single Innervated and Denervated Skeletal Muscle Cells in Mice.

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概要

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• We examined morphological differences and compared the Ca<SUP>2+</SUP>-dependence between acetylcholine (ACh)-contractures in normal and denervated skeletal muscle cells. ACh (1 μM -1 mM) contracted the normal cells into a jackknife-shape. The higher the concentration of external Ca<SUP>2+</SUP>, the greater the ratio of responding cells/total cells observed and the sharper the angles of the "jackknives". ACh contracted the denervated cells into a compression-form, and the contraction was dependent on the external Ca<SUP>2+</SUP> These results indicate that ACh-contractures in both normal and denervated cells are external Ca<SUP>2+</SUP>-dependent.

• 公益社団法人 日本薬理学会の論文

著者

• Nojima Hiroshi

  Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti

• Kimura Masayasu

  Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti

• Kimura Ikuko

  Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

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