EFFECTS OF HYPOGLYCEMIC COMPONENTS IN GINSENG RADIX ON BLOOD INSULIN LEVEL IN ALLOXAN DIABETIC MICE AND ON INSULIN RELEASE FROM PERFUSED RAT PANCREAS
スポンサーリンク
概要
- 論文の詳細を見る
Some fractions extracted from ginseng radix (HAKUSAN) caused hypoglycemic effect on alloxan diabetic mice. The effect was abolished by the i.v. injection of antisera against bovine insulin. The same doses of the ginseng fraction (10-50 mg/kg) produced an increase in the blood insulin level in alloxan diabetic mice. Normal mice loaded i.p. with glucose (2 g/kg or more) showed also such an increase. Insulin release from perfused rat pancreases was stimulated by the ginseng fraction (0.2 mg/ml), but the potency was not stronger than that of the sulfonylureas. It was demonstrated that glucose-induced insulin release was marked in the presence of the ginseng fraction. Impaired insulin responses to glucose in alloxan diabetic rats were increased by the fraction (0.5 mg/ml) to or above the control responses in normal rats. The enhanced effect was observed also in the presence of 100 μg/ml cycloheximide. These results indicate that some ginseng fractions stimulated insulin release, especially glucoseinduced insulin release from pancreatic islets and thereby lowered the blood glucose level.
- 公益社団法人日本薬学会の論文
著者
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Kimura Masayasu
Department of Cardiovascular Medicine, Medical Bioregulation, Yamaguchi University School of Medicin
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TANAKA Osamu
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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Kimura Masayasu
Department Of Cardiovascular Medicine Medical Bioregulation Yamaguchi University School Of Medicine
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Kimura Masayasu
Toyama Medical And Pharmaceutical University
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Kikuchi Takeo
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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WAKI ISAMI
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmace
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Waki Isami
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences
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CHUJO TADASHI
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmace
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HIYAMA CHIZUKO
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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YAMAZAKI KAZUO
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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Chujo Tadashi
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Hiyama Chizuko
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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Yamazaki Kazuo
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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Yamazaki Kazuo
Institut Fur Theoretische Physik Der Universitat Graz:physics Department College Of General Educatio
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Kimura Masayasu
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Tanaka Osamu
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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TANAKA Osamu
Institute for the Solid State Physics, University of Tokyo
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