DECREASING EFFECTS OF GLYCEROL-FRACTIONS EXTRACTED FROM OX DIAPHRAGM MUSCLES ON ACETYLCHOLINE-INDUCED CONTRACTIONS OF SMOOTH MUSCLES
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概要
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Extracts of 5% glycerol obtained from ox diaphragm muscles were fractionated into four (A, B, C and D) with (NH<SUB>4</SUB>)<SUB>2</SUB>SO<SUB>4</SUB>. The activity as acetylcholine (ACh) receptor-like substance containing fraction was evidenced as follows; the ACh-induced contraction of tracheal muscles decreased with addition of the fraction, and such could not be attributed to the reaction with ACh receptors of tracheal smooth muscles. Fraction D had the most potent activity in the presence of neostigmine. This reaction induced by fraction D was reversed by addition of <I>d</I>-tubocurarine(<I>d</I>-TC). Fraction D was fractionated into three (I, II and III) by gel filtration on Sephadex G-75 with 50 mM phosphate buffer (pH 7.5). The purified fraction III was identified by electrophoresis, UV and visible absorption spectrum, and ion-exchange chromatography to be myoglobin. Pure myoglobin also proved to have a decreasing effect on ACh-induced contraction.
- 社団法人 日本薬理学会の論文
著者
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Kimura Ikuko
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical & Pharmace
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Kimura Masayasu
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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