.BETA.-Eudesmol (a main component of Atractylodes lancea)-induced potentiation of depolarizing neuromuscular blockade in diaphragm muscles of normal and diabetic mice.
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概要
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Potentiating effects of β-eudesmol on neuromuscular blockade were investigated in phrenic nerve-diaphragm muscles of normal and alloxan-diabetic mice. Pretreatment with β-eudesmol potentiated the blocking effects of succinylcholine to a greater extent in diabetic muscles than in normal ones. This effect was saturated after 30-min pretreatment in normal muscles. Further potentiation was observed after 60-min pretreatment in diabetic muscles. These results suggest that β-eudesmol modifies the sensitivity of diabetic mice to depolarizing blockers so that they have a higher susceptibility to these compounds.
- 公益社団法人 日本薬理学会の論文
著者
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Tanaka Katsunao
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Muroi Masashi
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Kimura Masayasu
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Kimura Ikuko
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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