Intracellular Ca2+ and Mg2+ Regulation for Insulin-Stimulated Glucose Uptake into Mouse Diaphragm Muscles.

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概要

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• We investigated whether the changed levels of intracellular Ca<SUP>2+</SUP> and Mg<SUP>2+</SUP> in mouse skeletal muscles affected insulin-stimulated glucose uptake. Insulin alone had no effect on <SUP>45</SUP>Ca<SUP>2+</SUP> efflux and uptake. A23187 at 20 μM increased <SUP>45</SUP>Ca<SUP>2+</SUP> influx and inhibited insulin-stimulated <SUP>14</SUP>C-glucose uptake with normal external concentrations of Ca<SUP>2+</SUP> and Mg<SUP>2+</SUP> or in the absence of both cations. These results suggest that the increase in Ca<SUP>2+</SUP> influx into, and in Mg<SUP>2+</SUP> efflux from, skeletal muscles may inhibit insulin-stimulated glucose uptake.

• 公益社団法人 日本薬理学会の論文

著者

• Naitoh Takeshi

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut

• Kobayashi Shinjiro

  Department Of Chemical Pharmacology Toyama Medical And Pharmaceutical University

• Kimura Masayasu

  Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti

• Kimura Ikuko

  Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

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