Overproduction of N^ε-(Carboxymethyl)lysine-Induced Neovascularization in Cultured Choroidal Explant of Aged Rat(Pharmacology)

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概要

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• N^ε-(Carboxymethyl)lysine (CML) adduct, a major structure of advanced glycation end product, facilitated production of immature microvessels from choroidal explant cultured in fibrin gel. The present study was investigated an action of endogenous CML adduct on neovascularization of cultured choroidal explants of aged Wistar rats with 9 months of age. The number of microvessels budded from explants was counted under optical microscope and used as an index of in vitro neovascularization. Aged choroidal explants increased the neovascularization in an age-dependent manner. Anti-CML antibody decreased age-facilitated neovascularization as well as CML-human serum albumin (HSA)-facilitated neovascularization. Both the aged explant and CML-HSA-treated explant significantly released vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF) α and platelet-derived growth factor (PDGF)-B during the culture period. The release of TNF α and PDGF-B was earlier than that of VEGF from the aged explants. The antibodies against these factors decreased the CML-facilitated and age-facilitated neovascularization in the choroidal explants. The inhibitory capacity of anti-TNF α antibody was greater than those of anti-VEGF and anti-PDGF-B antibodies. In conclusion, endogenous CML adduct overproduced the neovascularization of the aged choroidal explant. The CML adduct releases TNF α which might induce the production and release of VEGF for the abnormal choroidal neovascularization in the patients of age-related macular degeneration.

• 公益社団法人日本薬学会の論文
• 2007-01-01

著者

• NOMURA Masaaki

  Department of Pharmacology and Pharmaceutics, Graduate School of Natural Science and Technology, Kan

• KOBAYASHI Shinjiro

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokuriku University

• NAGAI Ryoji

  Department of Medical Biochemistry, Kumamoto University Graduate School of Medical Sciences

• HAGINO Nobuyoshi

  Tulane University Health Sciences Center, Tulane University Hebert Center, Blds. 30, US-Japan Biomed

• Nomura Masaaki

  Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University

• NISHIOKA Tatsuo

  Department of Clinical Pharmacy, Graduate School of Natural Science and Technology, Kanazawa Univers

• Kobayashi Shinjiro

  Department Of Chemical Pharmacology Toyama Medical And Pharmaceutical University

• KIKUCHI Minoru

  Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Hokuriku University

• ISHIHARA Akina

  Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Hokuriku University

• Ishihara Akina

  Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University

• Kikuchi Minoru

  Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University

• Kobayashi S

  Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University:organizat

• Kobayashi S

  Kyoritsu Coll. Pharmacy

• Nagai Ryoji

  Department Of Biochemistry Kumamoto University

• Hagino Nobuyoshi

  Tulane University Health Sciences Center Tulane University Hebert Center

• Kobayashi Shinjiro

  Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University:organizat

• Nishioka Tatsuo

  Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University

• Kobayashi Shinjiro

  Department of Applied Chemistry, Faculty of Engineering, Kyushu University

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